ID   A3LQE7_PICST            Unreviewed;       726 AA.
AC   A3LQE7;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   Name=GCD6 {ECO:0000313|EMBL:ABN65195.2};
GN   ORFNames=PICST_81885 {ECO:0000313|EMBL:ABN65195.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN65195.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN65195.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   EMBL; CP000496; ABN65195.2; -; Genomic_DNA.
DR   RefSeq; XP_001383224.2; XM_001383187.1.
DR   AlphaFoldDB; A3LQE7; -.
DR   STRING; 322104.A3LQE7; -.
DR   GeneID; 4836820; -.
DR   KEGG; pic:PICST_81885; -.
DR   eggNOG; KOG1461; Eukaryota.
DR   HOGENOM; CLU_012507_1_0_1; -.
DR   InParanoid; A3LQE7; -.
DR   OMA; LAQSCKI; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd04197; eIF-2B_epsilon_N; 1.
DR   CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035543; eIF-2B_epsilon_N.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000313|EMBL:ABN65195.2};
KW   Protein biosynthesis {ECO:0000313|EMBL:ABN65195.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT   DOMAIN          550..723
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
SQ   SEQUENCE   726 AA;  82103 MW;  B9C5148D1AAF5D4B CRC64;
     MPPKNKKSKE SVQDERFQAI VLTDSFETRF MPLTSVKPRC LLPLANVPLI EYTLEFLAKA
     GVNEVHLMCS SHAEQIQQYI LNSKWNSKNS PFLIHTVMSL ESRSVGDAMR DLDNRGLITG
     DFLLVSGDVV TNIDFERAMN FHKQKKLQDK EHIVTMVLNQ ASPLHRTRSH VDPATFILDK
     KTDRCLFYQG IPPVDGAKSS ISIDPELIED IEDEFVIRND LIDCYVDICT PHVPQIFQDN
     FDYQTLRSDF LKGVLTSDLV KKSIYAYISE NSAEYAARVE SWATYDAVSQ DVLARWCYPL
     VPDANLIENN SYTYEFSHIY KEEKVVLAQS CKIGSCTSIG ANTTVGEGSS IKKSVIGRNC
     RIGKNVIINN SYIWENSVIE DNSVLNHTII AGDASIGSNV TLSPGSVIGF NVKIGNNKHI
     SHHVRIVEKP ILKDSFDSDS FDTDASDVDE DAQQPAIPHI ELNIKDIDLV GEDGDGYLYV
     SDRAVDDESE SEYGDQYSGI IYQFKHLNVS DDSIASISNR KGKKRSHSRT RRLSSNSVIS
     TDFEGGAFSD DEEEDFAKEA EATVHRALEN NHDLDTALLE LNTLRMSMNV TYHEVRLATC
     QVLLQKIVEY ITTDTLAAKE ATTKIFTQWG PMFKRQVFSE EEQVDLLNIL QDKIAKLDKA
     YNQIVLFLAV RILYELDIVE EDQILNWWKD NEGDEDKDIQ SVRTLTGQFI TWLQDAEEEE
     SDEESD
//