GenomeNet

Database: UniProt
Entry: A3LUS8_PICST
LinkDB: A3LUS8_PICST
Original site: A3LUS8_PICST 
ID   A3LUS8_PICST            Unreviewed;       947 AA.
AC   A3LUS8;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   07-JUN-2017, entry version 63.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=VPH3 {ECO:0000313|EMBL:ABN67012.2};
GN   ORFNames=PICST_67737 {ECO:0000313|EMBL:ABN67012.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 /
OS   NRRL Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN67012.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN67012.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-
RT   fermenting yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000499; ABN67012.2; -; Genomic_DNA.
DR   RefSeq; XP_001385041.2; XM_001385004.1.
DR   STRING; 322104.XP_001385041.2; -.
DR   EnsemblFungi; ABN67012; ABN67012; PICST_67737.
DR   GeneID; 4839578; -.
DR   KEGG; pic:PICST_67737; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; A3LUS8; -.
DR   KO; K02154; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002258};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:ABN67012.2};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    502    525       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    546    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    652       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    664    685       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    725    744       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    856    879       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    885    908       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   947 AA;  107753 MW;  5EE114B33CD0D2FF CRC64;
     MQPIQLSDDS SSVAPEAIFR SAPMTLVQFY VTIELARDMV YTLGNLGDVH FRDLNSKLTP
     FQRTFVSELR NIDTMESQLA FLNSIMIKYE TIKSDVFVNL KADMDPLPTT SEMDDMKQKI
     TTFYDRIKHL DNSYNVLNEQ KMAVVENRHV LNAVTDFHSS SLIGGYNESR ISLSLSDGAD
     DDNVALLNNR NNSMELGSET INLEESGFDA ISGTIVREKV PLLRNILWRT MRGNLYFHDV
     PIDNEKLFDY NATQEELVNK NVFIVYIHGD LLRTRVRRII QSLDGNIFDN VNGGASARAA
     TSSELNAKIT DLNNIVMTTK NHLIAELLIF QEAYPDYCFI VQRDKLIYQT LNKFDEDSTR
     RCLVGEGWIP TSDFGLIRQT LRHLVREKTR RGDGESDSQE SVPLTQQGSS PNPVSQTYTN
     LGSGNSSLFA IDDATDDFSE LEDEEYGSLI AIVNELSTNR TPPTYHNVNK FTSAFQSIID
     AYGIATYQEV NPGLATIVTF PFMFAIMFGD IGHGLIVLLI SLYLIKNEVH FGAMRNKDEI
     FEMAFNGRYI ILLMGLFSMY TGFLYNDIFS KTITLFKSGW VWNFPKDYDF TKDGPVTLVA
     EKAARTYPIG LDWAWHGAEN NLLFTNSYKM KLSVLMGFVH MNYSLFFSLV NYRYFKSRVD
     IIGNFIPGFL FMQSIFGYLS LTIVYKWSVD WLGKGKQPPG LLNMLINMFL APGKVEEQLY
     PGQKYIQVFL VLVALVCVPW ILVYKPLTLK RQNDRAIQLG YKDLHSQANH SIQLHEEMEA
     TQLEEDLNHD PDDDDFEISD DDFHFPNDIE PLHHNSTSHG EDGSDFNFGD IVIHQVIHTI
     EFCLNCVSHT ASYLRLWALS LAHAQLSTVL WTMTIQNAFY TTGNAGIAMV VALFGLWFIL
     TVCILVLMEG TSAMLHSLRL HWVEAMSKFF EGEGYAYEPF TFKSIDL
//
DBGET integrated database retrieval system