ID   A3LVH6_PICST            Unreviewed;      2351 AA.
AC   A3LVH6;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   01-MAY-2013, entry version 46.
DE   SubName: Full=Cell cycle checkpoint protein;
DE            EC=2.7.1.137;
GN   Name=MEC1; ORFNames=PICST_32127;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 /
OS   NRRL Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-
RT   fermenting yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- SIMILARITY: Contains 1 FAT domain.
CC   -!- SIMILARITY: Contains 1 FATC domain.
CC   -!- SIMILARITY: Contains 1 PI3K/PI4K domain.
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DR   EMBL; CP000499; ABN66780.2; -; Genomic_DNA.
DR   RefSeq; XP_001384809.2; XM_001384772.1.
DR   ProteinModelPortal; A3LVH6; -.
DR   STRING; 4924.PICST_32127; -.
DR   GeneID; 4839417; -.
DR   KEGG; pic:PICST_32127; -.
DR   HOGENOM; HOG000248362; -.
DR   KO; K02543; -.
DR   OMA; HCENILL; -.
DR   OrthoDB; EOG4TJ024; -.
DR   GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:GOC.
DR   Gene3D; 1.10.1070.11; -; 2.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003152; FATC.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR003151; PIK-rel_kinase_FAT.
DR   InterPro; IPR014009; PIK_FAT.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR012993; UME.
DR   Pfam; PF02259; FAT; 1.
DR   Pfam; PF02260; FATC; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF08064; UME; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SMART; SM00802; UME; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS51189; FAT; 1.
DR   PROSITE; PS51190; FATC; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Transferase.
SQ   SEQUENCE   2351 AA;  271088 MW;  41EA3C6B1CBADFBC CRC64;
     MSSNQHITSA ELRLFLDDVD RNIESDEGPH FRRLILYLFS FTNDKLFQLS QSELRDQDEE
     KLLQRLISTI ELVLTKKLHL LNLELNHNDY NKFLANEPSH LLYDWAISFA LHHIAKYHNK
     ISILNYLKSF VIQIISLVAT KLHSFKYTKQ IRTSLMSLME TNLQFLIHNL SSLPNTEIYQ
     SKLIITVHLF SLLNDYDVAN RLLLNLSSYQ LTFDSYARKI WFVLSEVNSQ SKQDSQLVGN
     LKSITILNLT DNLVLNDCIT WNQISLVLEW VIGYIRSELS KGDSTTKFNN FNLNKTISYS
     LLKVLRLCIE KDIAHNFMYC LNFNKLIIKI TTSIEDLHVP ALIVKSFHIL NYYCNLAINN
     TSIVASYQTS ANNRHIITPF NDKELESLRV QLVDRTSQDT HSIVSQLLSY LENDEMNEAQ
     EAEFSNRYVS PNFNYLEWIQ KVRAITVKSG STDAFSELYS QYMLITALGH FPCLVSNDFN
     FKVKECTKCG SGPMNKNYYD VIDLNRKPIP DSTEISIYYK EILCKYYLGT KAQFLHDNPL
     LCCNFLLSVY KLFASYGTPR GLISKEPVFK FTMQLLATNT NRDVRILATR ILPLYLLQPK
     DKVTVQNFKI IFQGISAIEF SPKSKRYLGE STIKAFVELA IVSEGEWLCV LFIKLIDLLG
     EKNEQHANYV YNGFITIASA KSLAPWRLLY PFLPSIAEII IKKPRLFSKM TDLLGIARKY
     FLNRTREYTT PRLLEYYKVD FIQEIADSCS MSKLDLVYKN LPRIIALYLV KDATINERYI
     MSVLRNISPT FKSVELSNLI TNIGETTWYI LLQIQVDDSN EKITNEGRIV DALTYVAKVS
     LDQKRKELPR QMDYVEYLLG DNVLELVQMF SENVHHIKGS KPYLEKVSSL RSIEYIINKN
     IQVVTAALGQ ISSCLQATLE IPDFQYYALR CWNVLVHKLP PSHLISLIDI IISLIFQKFQ
     NLDGSSKDLS IEILKRIYEE IKDKYNSYTL YYLSIPFLDH IQEYKPISGF RNVKQMSRIT
     IFSEFTRRIQ TNNEYVVQQA LYDLLNYCEK YQANCQLEYF REPTLEPYIT ELVRTILDTS
     SLFKNKNDHI STSCAKVLSV IGSLDSNKFN FKSVKHQIIV IQDFKDYREN SEFLIDFIET
     KVLKIFWASN DPMKQLFSAY AMQNFLQVLR LDPKVLTPSS QDHLLAVWNK FSDVAQSTLT
     PLLASKYYTP PSKYSPLSFP YFKISMKYET WLMEITSDLL KRPSKNIDGD ANEAKQTIFQ
     TCSKLIRDQD LSLCQHLLKY VSLSHIVNGN KGATTNIKEE FLNILHFDAT SSSPDRIEQL
     KSCLQSVLEV LDYFNEWVST ATQYLNNYSL DNSEASRIKK NIRYVNDFLG FIPMDLIAIK
     SAECDSYERT ILYLERCYRE GKVDDSFMLA NLNIGTTLQS MYSSINDYDA LNGVLKKFST
     SNLSEKLTTF QYNESWSLAQ ESFQVLGSVG DEESRIGSNT KLLMSLNDNG LYEEVLSTLS
     AKTSISDISS IPLDWSLVGL QSSIYSGDMY QMKKWLHIVN SLGKPHDVET LVNYELAKGI
     VFLSEGNRSD FEKAIQNLYG IIGTSLVPSI SSSFSRNTNL MNQLHSIYDL TMISQSNNEL
     LTGENEKILE ARLGNVDQGF DAQWKILKLH GVTNKIVKRE WKISEILLKY SALARKSNRL
     DISTRSIVQA MALNDERANI EYAKLLWAQG KQTEAIKSLA DILEENRFDN QERKADVQLK
     YAQWLDESNH LSSSAIIKEY NKSVELNPSW EKPYYDLGKY YNKIMESTND QTGYYEHQTV
     RHFLKALAVG HSFIFEALPK SITIWLDFAQ RKTRSREAER KLNQIVEDIK TCLNTIPLYV
     WYTAITQLLS RIVHEHQPSF EKLSLIIFNI IREYPRHSLW YVLSHANSND PTRRERINSV
     LRKVTNENRE YGSIVVNAKE LFSSLIKIAS FKIPKSPRAK RLSLRQDFKV DNLNNPYTSL
     VIPVRSNLEI RLPATNTVKF NAFPKSSSIT FDGFDDYVNI FFSLQMPRQV TIRGSDNKPY
     RLMVKRDDTR KDAKVVEFTT MINRLLLSSN EARKRGLQIS NYSVIPLAEN MGVIEFVTDV
     QTMKGIAGEQ RKRMGRSLNE RKIFMKLDDL QKQVKGAKAS DPEPLNKLVD VFKKILEDNP
     PVLHSWFIDQ FSDPTAWYLA RNQFTRSSAV MSMVGYIIGL GDRHCENILF FKKTGSVLHI
     DFDCLFDKGE TLPTPEIVPF RLTSNMIDAM GICGIEGSFR ITCEVTGSLL RENEAPLMNI
     LETLLYDPLL DWKSVQKPEA HLSKVRRKIR GLVNEKEGLP MNIHGQVDVL IQEASSIERL
     SQMYGGWSAY I
//