ID EIF3B_PICST Reviewed; 712 AA.
AC A3LY29;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=PICST_73391;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CP000500; ABN67905.1; -; Genomic_DNA.
DR RefSeq; XP_001385934.1; XM_001385897.1.
DR AlphaFoldDB; A3LY29; -.
DR SMR; A3LY29; -.
DR STRING; 322104.A3LY29; -.
DR GeneID; 4839799; -.
DR KEGG; pic:PICST_73391; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; A3LY29; -.
DR OMA; LWGGPQF; -.
DR OrthoDB; 5479191at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED; 1.
DR PANTHER; PTHR14068:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..712
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363824"
FT DOMAIN 37..124
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 191..229
FT /note="WD 1"
FT REPEAT 230..293
FT /note="WD 2"
FT REPEAT 301..339
FT /note="WD 3"
FT REPEAT 342..384
FT /note="WD 4"
FT REPEAT 452..493
FT /note="WD 5"
FT REPEAT 513..555
FT /note="WD 6"
FT REPEAT 566..604
FT /note="WD 7"
FT REGION 1..224
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REGION 1..98
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 712 AA; 81224 MW; 8E1CA303E6F4D5D0 CRC64;
MSLTEAEYHE LEKQVNLDDI DFSDLEEQYE VDVGLDNYVV VDGAPIAPEA KVPVLIKVLK
KLFNTVGKVV EGDEGIYMPL EDGKSKGYLF VQFETSEMAE AAIKQLHGKK LDQKHRLLVN
RLSDIEKYGV EGNVAAEFVE PELPPFKSHG YLKSWLQDPQ GRDQIALHHS ETFGVFWNKK
KSDPEPVFEP RKFFTSKYAK FSPKGTYLFS IHPQGVQSWG GADFSSIDKF MHNQVRLVDF
SPNEKYMVTL SPLPITAPDS AAERAVFPFG PESYGHKLVI WDLTTGEPAR TFALPPHLEG
QKEMPWPLVK WSHDDKYCAR QGPGALAVYE TPSFQLLDKK LIKIDDIVDF EWAPAGVHLA
NNKSENGHHL LSYWTPESSN QTARVAVMQI PTRQILRTVN LFQVSDCKMH WQSEGKLLCV
KVDRHTKSGK TIFTNLEFFK TTEKDIPVEK LELKEIVINF AWEPKSERFV IISRLDDGNL
NSAIPKNIID FYAPDVNGKG KSATSVYKSY KTITDKHSNT VFWSPKGRYV VVATISRSNG
EIEFFDVSFD DSNKNAPANV KLLKNDKFSG MTNISWDPSG RFVATWSSSW LHTIENGYKL
YEFTGNLLRD DSIDQFKEFI WRPRPASLLN SADRKKVRAN LREYSAQFEE SDAMEADAAL
RELIYARRRA LEDWKAYRAK HASKAVKANE VQAEIIEEIK EEIIEEKEEI VE
//
