ID A3LY76_PICST Unreviewed; 235 AA.
AC A3LY76;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN Name=PNC1 {ECO:0000313|EMBL:ABN67930.2};
GN ORFNames=PICST_33075 {ECO:0000313|EMBL:ABN67930.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN67930.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN67930.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; CP000500; ABN67930.2; -; Genomic_DNA.
DR RefSeq; XP_001385959.2; XM_001385922.1.
DR AlphaFoldDB; A3LY76; -.
DR STRING; 322104.A3LY76; -.
DR GeneID; 4840398; -.
DR KEGG; pic:PICST_33075; -.
DR eggNOG; KOG4003; Eukaryota.
DR HOGENOM; CLU_068979_13_0_1; -.
DR InParanoid; A3LY76; -.
DR OMA; DFVDSWP; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008936; F:nicotinamidase activity; IEA:UniProtKB-EC.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR11080:SF2; LD05707P; 1.
DR PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABN67930.2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT DOMAIN 136..213
FT /note="Isochorismatase-like"
FT /evidence="ECO:0000259|Pfam:PF00857"
SQ SEQUENCE 235 AA; 26602 MW; 46C8B6501A96BD5A CRC64;
MSQRKVALAV IDLQEDFLPP HGSLAVAQGR SVIPLINDLV TNRQFKWSAV IATQDWHPSD
HTSFASQHGV APFTELEFKH PLDEKDPVTN EVIIKKQVVW PDHCVQESSG ACIDASFLGN
FNSISPNIVK TVVKKGYLSD REYYSCFQDT WGLHHTEMEK FLRDNKITDV IFVGLAYDYC
VFNSAKDSAA DGFNTYVLKK CCKSVYPEKE AETDELYRKA NVTIIEDDSY VDLLK
//
