ID A3LYI5_PICST Unreviewed; 417 AA.
AC A3LYI5;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 24-JAN-2024, entry version 97.
DE SubName: Full=Aspartic proteinase {ECO:0000313|EMBL:ABN67644.2};
DE EC=3.4.23.24 {ECO:0000313|EMBL:ABN67644.2};
GN Name=APR1 {ECO:0000313|EMBL:ABN67644.2};
GN ORFNames=PICST_73446 {ECO:0000313|EMBL:ABN67644.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN67644.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN67644.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; CP000500; ABN67644.2; -; Genomic_DNA.
DR RefSeq; XP_001385673.2; XM_001385636.1.
DR AlphaFoldDB; A3LYI5; -.
DR STRING; 322104.A3LYI5; -.
DR MEROPS; A01.018; -.
DR GeneID; 4840317; -.
DR KEGG; pic:PICST_73446; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_3_4_1; -.
DR InParanoid; A3LYI5; -.
DR OMA; KYDHDAS; -.
DR OrthoDB; 615305at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0000324; C:fungal-type vacuole; IEA:InterPro.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05488; Proteinase_A_fungi; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR033819; Saccharopepsin.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:ABN67644.2};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002655177"
FT DOMAIN 103..414
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 121
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 306
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 134..139
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 340..373
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 417 AA; 45095 MW; 04A0F3C08144B9EF CRC64;
MHFSLSLLTT IATALLALPV DAGKHSAKLK KVPTEETLDA NTFREYTDAL SNKYMNMFNA
AAGNPVVPNV MGMANQAQVP FVNPEGKKGA HEAPLTNYLN AQYFTEISLG TPAQQFKVIL
DTGSSNLWVP SQECSSLACF LHTKYDHDSS STYKANGSEF SIQYGSGAME GYVSQDTLAI
GDLVIPKQDF AEATSEPGLA FAFGKFDGIL GLAYNTISVN KIVPPVYNAL AQGLLDEPQF
AFYLGDTKKD ENDGGLATFG GYDESAFTGK ITWLPVRRKA YWEVSFEGIG LGDEYAELDN
TGAAIDTGTS LITLPSSLAE IINAKIGATK SWSGQYQIDC EKQDTLPDLT LNFAGYNFTL
TAHDYILEVG GSCISVFTPM DFPKPIGDLA IIGDAFLRRY YSIYDLKKDA VGLATSK
//