ID A3N3B0_ACTP2 Unreviewed; 258 AA.
AC A3N3B0;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Probable macrolide-specific efflux protein {ECO:0000313|EMBL:ABN74896.1};
GN Name=macA {ECO:0000313|EMBL:ABN74896.1};
GN OrderedLocusNames=APL_1814 {ECO:0000313|EMBL:ABN74896.1};
OS Actinobacillus pleuropneumoniae serotype 5b (strain L20).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=416269 {ECO:0000313|EMBL:ABN74896.1, ECO:0000313|Proteomes:UP000001432};
RN [1] {ECO:0000313|EMBL:ABN74896.1, ECO:0000313|Proteomes:UP000001432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L20 {ECO:0000313|EMBL:ABN74896.1,
RC ECO:0000313|Proteomes:UP000001432};
RX PubMed=18065534; DOI=10.1128/JB.01845-07;
RA Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M.,
RA Nash J.H.;
RT "The complete genome sequence of Actinobacillus pleuropneumoniae L20
RT (serotype 5b).";
RL J. Bacteriol. 190:1495-1496(2008).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000569; ABN74896.1; -; Genomic_DNA.
DR AlphaFoldDB; A3N3B0; -.
DR STRING; 416269.APL_1814; -.
DR EnsemblBacteria; ABN74896; ABN74896; APL_1814.
DR KEGG; apl:APL_1814; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_1_6; -.
DR Proteomes; UP000001432; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001432}.
FT DOMAIN 4..208
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 41..125
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 258 AA; 28720 MW; 02BB04EEE00A0107 CRC64;
MQATEQVDIG AQVSGQIKHI LVQEGQKVKK GELLAVIDPR LAETELKLAK AELANASANL
DTKKINLKQL QSDWERHQRL IRTNATSQKE TEEAKSRLNT AKAELQIAQN NLDIAKIRVE
KAETELGYTE IRSPLDATVI SVFAQNGQTL VTTQQVPVLM KLANIDTMKV NTKISEADVI
HIQAGAPTSF TLLGESDSQF HGQLDMVKLA PVHITDTTEN TNNAIYYYAT FKVPNPDHRL
RISMTGRCTI MLDKREMC
//
