ID MDH_BURP0 Reviewed; 327 AA.
AC A3P7Q9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Malate dehydrogenase;
DE EC=1.1.1.37;
GN Name=mdh; OrderedLocusNames=BURPS1106A_A2336;
OS Burkholderia pseudomallei (strain 1106a).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=357348;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1106a;
RA DeShazer D., Woods D.E., Nierman W.C.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC oxaloacetate (By similarity).
CC -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
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DR EMBL; CP000573; ABN95269.1; -; Genomic_DNA.
DR RefSeq; YP_001076369.1; NC_009078.1.
DR ProteinModelPortal; A3P7Q9; -.
DR SMR; A3P7Q9; 3-325.
DR STRING; 357348.BURPS1106A_A2336; -.
DR EnsemblBacteria; ABN95269; ABN95269; BURPS1106A_A2336.
DR GeneID; 4904964; -.
DR KEGG; bpl:BURPS1106A_A2336; -.
DR PATRIC; 19230626; VBIBurPse14980_5928.
DR eggNOG; COG0039; -.
DR HOGENOM; HOG000220953; -.
DR KO; K00024; -.
DR OMA; NCLIASK; -.
DR ProtClustDB; PRK05442; -.
DR BioCyc; BPSE357348:GHVF-2192-MONOMER; -.
DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR Gene3D; 3.40.50.720; -; 1.
DR Gene3D; 3.90.110.10; -; 1.
DR HAMAP; MF_01517; Malate_dehydrog_2; 1; -.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR23382; PTHR23382; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR SUPFAM; SSF56327; Lactate_DH/Glyco_hydro_4_C; 1.
DR TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
DR PROSITE; PS00068; MDH; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 327 Malate dehydrogenase.
FT /FTId=PRO_0000294379.
FT NP_BIND 12 18 NAD (By similarity).
FT NP_BIND 130 132 NAD (By similarity).
FT ACT_SITE 188 188 Proton acceptor (By similarity).
FT BINDING 93 93 Substrate (By similarity).
FT BINDING 99 99 Substrate (By similarity).
FT BINDING 106 106 NAD (By similarity).
FT BINDING 113 113 NAD (By similarity).
FT BINDING 132 132 Substrate (By similarity).
FT BINDING 163 163 Substrate (By similarity).
SQ SEQUENCE 327 AA; 35015 MW; 2E919ABA6D3F67B3 CRC64;
MAKPAKRVAV TGAAGQIAYS LLFRIANGDL LGKDQPVILQ LLDLPQAQAA VKGVVMELDD
CAFPLLAGVV ITDDPKVAFK DADVALLVGA RPRSKGMERK DLLSANAEIF TVQGAALNEV
ASRDVKVLVV GNPANTNAYI AMKSAPDLPK KNFTAMLRLD HNRALSQLAA KSGKPVASIE
KLAVWGNHSP TMYPDFRFAT AEGESLLKLI NDDVWNRDTF IPTVGKRGAA IIEARGLSSA
ASAANAAIDH VRDWVLGTNG KWVTMGIPSD GSYGIPEDII YGVPVICENG EYKRVEGLEI
DAFSREKMDG TLAELLEERD GVAHLLK
//
