ID A3SM72_ROSNI Unreviewed; 815 AA.
AC A3SM72;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=FAD dependent oxidoreductase/aminomethyl transferase {ECO:0000313|EMBL:EAP78453.1};
GN ORFNames=ISM_09150 {ECO:0000313|EMBL:EAP78453.1};
OS Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=89187 {ECO:0000313|EMBL:EAP78453.1, ECO:0000313|Proteomes:UP000005954};
RN [1] {ECO:0000313|EMBL:EAP78453.1, ECO:0000313|Proteomes:UP000005954}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-591 / DSM 15170 / ISM
RC {ECO:0000313|Proteomes:UP000005954};
RA Moran M.A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAP78453.1}.
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DR EMBL; AALY01000001; EAP78453.1; -; Genomic_DNA.
DR RefSeq; WP_009813852.1; NZ_CH724156.1.
DR AlphaFoldDB; A3SM72; -.
DR STRING; 89187.ISM_09150; -.
DR eggNOG; COG0404; Bacteria.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_007884_11_0_5; -.
DR OrthoDB; 7156675at2; -.
DR Proteomes; UP000005954; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005954};
KW Transferase {ECO:0000313|EMBL:EAP78453.1}.
FT DOMAIN 8..369
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 373..426
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 430..700
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 725..807
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 815 AA; 89242 MW; BEC2BD889C2576FA CRC64;
MSLPTQARVV IIGGGVVGCS VAYHLAKLGW KDVVLLERKQ LTSGTTWHAA GLIGQLRASQ
NMTKLARYSA ELYKGLEAET GVATGLRQGG SVSAALTNER LEELYRQAAM ARAFGVPVEE
LSPKEVKEKY EHINLDGVTG GVWLPTDGQA DPANIALALA KGARQNGALV KERIKVTGIK
RKDRRVTGVD WAADDGSEQG HIACDMIVNC AGMWGHEVGR MAGVNVPLHA CEHFYIVTEG
ISGLSQMPVL RVPDECAYYK EDAGKILLGA FEPHSKPWGM NGIPENFEFD QLPEDFDHFE
PILEAACNRM PLLAEAGIHT FFNGPESFTP DDAYHLGLAP EMDNVWVAAG FNSIGIQSAG
GAGHALSQWM DSGEKPFDLG DVDISRMQPF QGNKHYLFER SKETLGLLYA DHFPYLQKRT
ARGIRRTPFH HHLLEKGAVM GEIAGWERAN WFANEGQERE YQYSWKRQNW FENARAEHMA
IREGVGMYDM SSFGKIRVEG PDAEAFLNYV GGGDYSVPVG KIVYTQFLNS RGGIEADVTV
TRMSETAYLV VTPAATRLAD QTWMERHKGN FNVVITDVTP GEGVLAVMGP KARDVLQAVS
PNDFSNEVNP FGTAQEIELG MGLARVHRVT YVGELGWEIY VSADMAGHAF ETLYEAGQAH
GLKLCGMHMM DSCRIEKGFR HFGHDITAED HVLEAGLGFA VKTAKPEFIG RDAVLRKKDE
GLAARMVQFK LTDPEPLLYH NEPVIRDGEI VGYLSSGSYG HALGGAMGLG YVPCKGESAA
DVLASTYEID VAGTRVRAEA SLKPMYDPKG ERAKA
//
