ID   A3U7P7_CROAH            Unreviewed;       956 AA.
AC   A3U7P7;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Peptidase S8 and S53, subtilisin, kexin, sedolisin {ECO:0000313|EMBL:EAP88264.1};
GN   OrderedLocusNames=CA2559_05875 {ECO:0000313|EMBL:EAP88264.1};
OS   Croceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Croceibacter.
OX   NCBI_TaxID=216432 {ECO:0000313|EMBL:EAP88264.1, ECO:0000313|Proteomes:UP000002297};
RN   [1] {ECO:0000313|EMBL:EAP88264.1, ECO:0000313|Proteomes:UP000002297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-628 / HTCC2559 / KCTC 12090
RC   {ECO:0000313|Proteomes:UP000002297};
RX   PubMed=20639333; DOI=10.1128/JB.00733-10;
RA   Oh H.M., Kang I., Ferriera S., Giovannoni S.J., Cho J.C.;
RT   "The complete genome sequence of Croceibacter atlanticus HTCC2559T.";
RL   J. Bacteriol. 192:4796-4797(2010).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
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DR   EMBL; CP002046; EAP88264.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3U7P7; -.
DR   STRING; 216432.CA2559_05875; -.
DR   KEGG; cat:CA2559_05875; -.
DR   eggNOG; COG1404; Bacteria.
DR   HOGENOM; CLU_328936_0_0_10; -.
DR   Proteomes; UP000002297; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00306; Peptidases_S8_S53; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR   PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002297};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          158..424
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        166
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        193
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        389
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   956 AA;  104651 MW;  F17F8C0B20E566CB CRC64;
     MLSLSTTLLS QEYKSFYLEL ASGIGVDLLD GSQIVIQPDQ TIKLVTNQTH PIFDFLNSKP
     FYSIEKAFPM TSLPRLKKVY IISIKDDTLV TDFVNNTGIT YFKEIDDDNN ILTSTTTAVN
     NTQISIPNDY EDLLYGGNNA SLELINAPLA WAITTGDSNI LVGVVDSSYE LNHPDLTGQI
     VNNIEVVPSN FSHGTAVASI IAANTDNNEG LSSLGRDLKL VTATCGGGGN NLVSGLEELA
     DYPGVRVINC SWRICEGSPV KTYLDDVMDY VRTKDILVVA SAGNGVQGDG TVKGCDSDGN
     GYGYPGSYDD AISVTGVGHR FSIGTLQDNI PGQTKSWIDV HRQLPDNPNN FASHTHNDKV
     NVSAPGIYVL SATETSNNQT GYTAGIGTSS STPLASALAG LIFSINPNFT ATQVKDIIES
     TTDNIYDIDL NQPYIGELGT GRINAYAAVL KAQCLTNPES GLDLAMQNSQ LDNFEEPDTL
     TTQPYRSKDI WVRNQDDGLL VKEHQNPEYD SNNPNYVYVR VTNSSCDSST GSDPLKLYWA
     KANTALSWPD HWDGSLTMTD PITGEDILMG DQIGTVNIPP LDIGQEAILT FEWLVPNPED
     YENINPNPWH FCLLARIDTP NDPMTTPEND NIVLNVWNNN NIVWKNTTVV DVVENSSNYG
     GVVAVGNYSN QQQSFDLVFV KDANEKGKAI YEEAEVGLEM DTTLYNAWQD GGKSQSQLKS
     TKDDYKKILT TNNSKLGNII LDAGEIGTLY VSFNFFTNQS TSKDKFALSV LQQDATTGSL
     IGGEEYIINK KTSSSFRANA GEDQDIKKDE FIVLSATPIN EDVTFNWYDQ NNTLLYSGEN
     VLVNPEFTST YKLEVISNLN GFKDYDHVDI TVNPFYLESL IPNPANNLVT VQYKVDEASS
     AYLSVVNTAT GQHHNYILDT TQTSRLLDIS NLSSGIYSII LVCDGEIQDS LNLSKL
//