ID A3VM18_9RHOB Unreviewed; 1791 AA.
AC A3VM18;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN ORFNames=RB2654_11939 {ECO:0000313|EMBL:EAQ10710.1};
OS Maritimibacter alkaliphilus HTCC2654.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Maritimibacter.
OX NCBI_TaxID=314271 {ECO:0000313|EMBL:EAQ10710.1, ECO:0000313|Proteomes:UP000002931};
RN [1] {ECO:0000313|EMBL:EAQ10710.1, ECO:0000313|Proteomes:UP000002931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2654 {ECO:0000313|EMBL:EAQ10710.1,
RC ECO:0000313|Proteomes:UP000002931};
RX PubMed=20729358; DOI=10.1128/JB.00873-10;
RA Thrash J.C., Cho J.C., Ferriera S., Johnson J., Vergin K.L.,
RA Giovannoni S.J.;
RT "Genome sequences of Pelagibaca bermudensis HTCC2601T and Maritimibacter
RT alkaliphilus HTCC2654T, the type strains of two marine Roseobacter
RT genera.";
RL J. Bacteriol. 192:5552-5553(2010).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ10710.1}.
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DR EMBL; AAMT01000027; EAQ10710.1; -; Genomic_DNA.
DR STRING; 314271.RB2654_11939; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_000965_1_0_5; -.
DR Proteomes; UP000002931; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR CDD; cd01100; APPLE_Factor_XI_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00223; APPLE; 1.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002931}.
FT DOMAIN 6..83
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 1791 AA; 191776 MW; 5C6CF37E0E961F0D CRC64;
MAQDLVPDRR FVLHRDVDFF GSDLQSIFDT SLENCESACL GDTQCRAFTF NTRNSSCFLK
SSISDEAEYS GAFSGEIVNE PQAVLAAAAD REAELMAFLR PYDISAAAQE ARWISNDYVA
GGWTAEDLSR IALDAEREGN FVNAYRNMGA ATVVSGAGGD WLEYARLTYA AANVTTENSE
RRRLMQQAFE ASIAAYARLS NPAARANALV IMAETLEQLD RGRDMIPALR LAQELSPRDD
TSAALDRAVG LYGFRVTDTE VQSDAAQPRI CASFSEPLIE TGQDYSDFVQ SETSGLAVTA
SGSQLCVAGV DHGQRYTITL RSGLPAANGE ALRAPVQVTH YVRDRSPSVV FPGKAYVLPR
TEDAGLPVIA VNADELALKL MKVSDRNLVR TIQENILGNS IDPWMSNYLE DEMASVVWTG
TASVSSELNT DVTTRLPIGE AIADMEPGVY ALQAAIEGED PYDTPPATQW FVISDIGLTS
MWGADGLHVF ARSLTSADAM EGMSVELVSN ANEVIGTATT DAMGYANFPA AMTMGQGSAA
PALVVAEGEN DLVYLSLRGP EFDLSDRGVE GNPAAPPIDV FLTTDRGAYR AGETINATAL
ARDGMAEAIP GLPLTAILTR PDGVEYSRQV SDGAGAGGHV YALPVSGAAP RGTWRLDLYT
DTEEPALAST TLLVEDFLPE RIDFDLSLPT GPVSADSAPT LGIDARYLFG APGADLDYEG
DIRLTAADSL DAFPGYRFGM WEDELYPQYG SVPSGTTDEA GQAQTTLSFP EIDAPGRPLN
ATVTVRVKEG SGRPVERQAS LAVTPATDLI GIKPKFDGDV SENSTATFDL IGLGPDLAGK
AMEVTWAVNR VRTRYQWYSS DGYWDWEPVT TREQVATGTA TLSADPVEVS AQVEWGRYEI
VVSRTTGAYL ASSMDFYAGW YVPADVSETP DMLEMSLDAE GYAPGDTATL RILPRNPGTA
LVTVVSNRLI HMEAVAVDGE TTVSLPVTEE WGAGAYVTAS LIQPLDEGKG RNPTRALGLA
HASVDPGDHR LSVGLDAPET AKPRGPMEVA VTVDGTRDGE TAYVTLAAVD QGILNLTSFE
DPDPEDHYFG QRRLGMGIRD LYGNLIDGMT GQMGEIRSGG DAAASMRMQA PPPTEELMAQ
FFGPLEVVDG RATATVDLPE FNGSVRLMAV AWSETGVGQA GGDVLVRDPV VMTASVPRFM
APGDEARMLL ELTHASGPTG DVTVTATSAG LQIGGGVLAD DITLGEGETA RVSVPIAAVS
EGIHQIALVL KTPSGEELTK TLTIPVETLD PEVVRQNRFT LAAGDTFTFT QDVFDGLTLA
SARATIAAGP LAKIDAPGLL DRLDRYPYGC TEQQTSRALP LLYMGGVAEA MGLEDRDDLP
QRVNEAIEAI LSNQSSSGSF GLWRPDSGDM WLDSFVSDFL SRARAQGYAV PDTAFRAAMD
NLRNRVNYYP DFENGGQDLA YALYVLAREG AAAMGDLRYY ADVKAAEFDG PLAAAQLGAA
LAAYGDPTRA DRMFAQAADL MAQPEPEGQI WRADYGTDLR DAAAVLTLAV EAGTQTVDRT
ALLNRIAQGD RYWSTQEATW SLLAANALLE DAPNAGLVLN GEPMTGPMVE VMNPVSLSRP
WTVENTGDGP VDITLAAFGV PTQPEPPTSN GYTIGRQYYS MEGEPVDVSR VAQGERLVTV
VTVTPQGYSD GRLMVSDPLP AGFEIDNPNL IRGGDIKALD WLQLTSDLRN SEFRQDRFLA
AVDWQSDRAF RLAYIVRAVT PGTFHHPAVS VEDMYRPDYR ATGETGTVVI E
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