ID A3WWZ9_9BRAD Unreviewed; 432 AA.
AC A3WWZ9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=tRNA and rRNA methylase {ECO:0000313|EMBL:EAQ35490.1};
GN ORFNames=NB311A_18536 {ECO:0000313|EMBL:EAQ35490.1};
OS Nitrobacter sp. Nb-311A.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Nitrobacter.
OX NCBI_TaxID=314253 {ECO:0000313|EMBL:EAQ35490.1, ECO:0000313|Proteomes:UP000003725};
RN [1] {ECO:0000313|EMBL:EAQ35490.1, ECO:0000313|Proteomes:UP000003725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nb-311A {ECO:0000313|EMBL:EAQ35490.1,
RC ECO:0000313|Proteomes:UP000003725};
RA Waterbury J., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ35490.1}.
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DR EMBL; AAMY01000011; EAQ35490.1; -; Genomic_DNA.
DR RefSeq; WP_009800023.1; NZ_CH672421.1.
DR AlphaFoldDB; A3WWZ9; -.
DR STRING; 314253.NB311A_18536; -.
DR HOGENOM; CLU_005316_0_2_5; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000003725; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22807:SF77; SUN PROTEIN; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000003725};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 145..432
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 361
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 262
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 308
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 432 AA; 46951 MW; 7004DB9D1DF8B422 CRC64;
MTPAARLSAA IEVMKTIDGQ RVPAAKALKE WGAAHRFAGS GDRAAISGLV YDVLRRQASS
AWIMDDDTPR GRLLGMLRLE RGMNADVIAS LCDGSRFAPE PLTDGEWQAL TARSLQEAPA
HVAGDYPEWL DVYLAEAFGD DRAAETAAMA RRAPLDLRVN TLKAKRDKVL GSLRHLGVTA
TPWSPLGLRI MLGADARNPG IQAEEEFIKG AVEVQDEGSQ VAALLSGVRP GEQVIDLCAG
AGGKTLTLAA MMQGRGRLIA TDRDKRQLAP IHERLSRAGV HNAEIRSPKG EAEPLSDIRE
SADLVLIDAP CTGTGTWRRN PDAKWRMRPG ALEVRLRDQS EVLDRAAGFV KPGGRVAYVT
CSVLPQENSE QIRKFISRHQ DFTVMPPSKV ASMLWDKADD FLAAVYVSNE GLLMTPRRTG
TDGFFVSILA KR
//
