ID A3YG70_9GAMM Unreviewed; 1005 AA.
AC A3YG70;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Sarcosine oxidase, alpha subunit {ECO:0000313|EMBL:EAQ63845.1};
GN ORFNames=MED121_05643 {ECO:0000313|EMBL:EAQ63845.1};
OS Marinomonas sp. MED121.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Marinomonas.
OX NCBI_TaxID=314277 {ECO:0000313|EMBL:EAQ63845.1, ECO:0000313|Proteomes:UP000003436};
RN [1] {ECO:0000313|EMBL:EAQ63845.1, ECO:0000313|Proteomes:UP000003436}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED121 {ECO:0000313|EMBL:EAQ63845.1,
RC ECO:0000313|Proteomes:UP000003436};
RA Pinhassi J., Pedros-Alio C., Ferriera S., Johnson J., Kravitz S.,
RA Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R.,
RA Venter J.C.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ63845.1}.
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DR EMBL; AANE01000017; EAQ63845.1; -; Genomic_DNA.
DR RefSeq; WP_009835362.1; NZ_CH672433.1.
DR AlphaFoldDB; A3YG70; -.
DR STRING; 314277.MED121_05643; -.
DR HOGENOM; CLU_011963_0_0_6; -.
DR OrthoDB; 5287468at2; -.
DR Proteomes; UP000003436; Unassembled WGS sequence.
DR GO; GO:0008115; F:sarcosine oxidase activity; IEA:InterPro.
DR GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
DR Gene3D; 3.10.20.440; 2Fe-2S iron-sulphur cluster binding domain, sarcosine oxidase, alpha subunit, N-terminal domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR042204; 2Fe-2S-bd_N.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR006277; Sarcosine_oxidase_asu.
DR InterPro; IPR041117; SoxA_A3.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR01372; soxA; 1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF17806; SO_alpha_A3; 1.
DR PIRSF; PIRSF037980; SoxA; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 170..424
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 521..604
FT /note="SoxA A3"
FT /evidence="ECO:0000259|Pfam:PF17806"
FT DOMAIN 620..884
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 911..997
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 1005 AA; 109499 MW; 8ECABD4A1B9FB90B CRC64;
MSQNKRLDSG GRIDRKKVIN FSFDGKSYKG FDGDTLASAL LANGVDIIAR SFKYSRPRGI
TGHGSEEPNG VIQLGTGAST IPNVRATQQE LYAGLVANPV AGWPSVNFDL MATLGKAGAM
MPPGFYYKTF MYPQKLWMTY EHFIRKAAGL GKAPTAPDPD TYDKVNHHCD VMIVGAGPAG
LSAALAAAKT GARVIIADEQ NEMGGSLLST TQMINGAPAS AWLKDTIEAL EDYSNVNVLP
RSTVMGYYDH NFLAVIERRT DHLGEISPRG ARQRMHRVRA KQVILAPGAQ ERPLIFANND
IPGVMLASSI SVYLNRYAVA PGNALVVSTA NDSGYQAAID WHKAGRKVIG IADSRAQSSG
ELVEEAKKLG LKIWFSHAVI EAKGSRRVYA ATVAPINAEG TQVTGASQNY DCDIIATSGG
WSPVVHLSCH TGSRPVWNDD IIGFLPGKTV QKQHCVGSLM GQHQLSDSLE QGLVIGAQAA
CEAGFGDGSN SIKVPSVDLV KTGQAQALFL VPHSKSVSRA PKQFVDMQND VTAAGIELAT
REGFESIEHV KRYTALGFGT DQGKLGNING MAVAAQSLNK TIAETGTTIF RPSYTPTTFG
AIAGRDTDSL FDPIRYTAMQ SWHEANGALF EDVGQWKRPW YFPKPGETMQ QTLDRECLAT
RNSVGILDAS TLGKIDIQGK DAREFLNRVY TNAWSKLAVG KCRYGLMLKE DGMIMDDGVT
SCIADDHFIL TTTTGGAANV LEWLELWHQT EWPELDVYMT SVTDHWSTMT ISGPNSRKVL
AKVCDDIDLD KDSFKFMDWR SGTVAGVKSR VFRISFTGEL SYEINVQANH GLHVWEAIME
AGKEFDITPY GTETMHVLRA EKGFIIVGQD TDGSVTPQDM DMSWCIGKNK EFSFIGKRSF
TRPDTARTDR KQFVGLKPKD ANVILPEGAQ AVRDPNESIP MTMVGHVTSS YYSAVLGHSF
ALAVIKDGHN RKGESVYFPL ADGRTIEAEI TDYVFYDAKG EKQHV
//
