ID A4A4G9_9GAMM Unreviewed; 1107 AA.
AC A4A4G9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=KT71_15581 {ECO:0000313|EMBL:EAQ99104.1};
OS Congregibacter litoralis KT71.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Congregibacter.
OX NCBI_TaxID=314285 {ECO:0000313|EMBL:EAQ99104.1, ECO:0000313|Proteomes:UP000019205};
RN [1] {ECO:0000313|EMBL:EAQ99104.1, ECO:0000313|Proteomes:UP000019205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT71 {ECO:0000313|EMBL:EAQ99104.1,
RC ECO:0000313|Proteomes:UP000019205};
RX PubMed=17299055; DOI=10.1073/pnas.0608046104;
RA Fuchs B.M., Spring S., Teeling H., Quast C., Wulf J., Schattenhofer M.,
RA Yan S., Ferriera S., Johnson J., Glockner F.O., Amann R.;
RT "Characterization of a marine gammaproteobacterium capable of aerobic
RT anoxygenic photosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:2891-2896(2007).
RN [2] {ECO:0000313|EMBL:EAQ99104.1, ECO:0000313|Proteomes:UP000019205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT71 {ECO:0000313|EMBL:EAQ99104.1,
RC ECO:0000313|Proteomes:UP000019205};
RX PubMed=19287491; DOI=10.1371/journal.pone.0004866;
RA Spring S., Lunsdorf H., Fuchs B.M., Tindall B.J.;
RT "The photosynthetic apparatus and its regulation in the aerobic
RT gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.";
RL PLoS ONE 4:E4866-E4866(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ99104.1}.
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DR EMBL; AAOA02000001; EAQ99104.1; -; Genomic_DNA.
DR RefSeq; WP_008295549.1; NZ_CM002299.1.
DR AlphaFoldDB; A4A4G9; -.
DR STRING; 314285.KT71_15581; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_009270_0_0_6; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000019205; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:EAQ99104.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000019205}.
FT DOMAIN 2..486
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 487..764
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1107 AA; 122391 MW; 3802BE6182346BD9 CRC64;
MTPVDNEARL RAVDPGLSVC VSAPAGSGKT ALLVQRFLGL LARVSEPESV VAITFTRKAA
AEMRARVVGA LQGAAEGVKA RNPHEEALMA AARAVAEHDG SRGWGLLDNP SRLRIQTIDS
FCGYLTRQMP VLSGCGGQVT ATDDSRVLYR EAIENFLHGE LNRRQDDKAR DIETLLLHLD
NNWDSALELL SKLLQRREQW QPVFGGGGLH GDAQQNVLEI TESLVRYRLE LLQERFAAHM
QQLITLMDYR EQNLKRGLLF SGDCSDLASW RGVAALLLTG KGEWRKTVTV RDGFPAGKGE
PAELKAQMLA LLSTLREEDD GALLGELRQV VLLPDVDDEP AHWDVLVAVT RLLPRLGAEL
LLVFQQKGEV DHAQIAMAAL DALGTDREPT DLALRLDHSI EHLLVDEFQD TSSVQFELIR
RLTRGWHEHN EANPQGPRTL LLVGDAMQSI YGFREANVGL FIRARNEGVG DLSLTPLDLQ
VNFRSQQGLV EWTNAHFQRG FPQVDDAQLG AVQFREAIAA RAPDEAPEFA LFTGDGGQAA
EIEALCDKLA EGVARDDVES IAVLGRSRTQ LRPILAALRA RDIDVAARDL DTLAQRPLIR
DLLTLTTVLC DRFDRFAWLS LLRTPAIALD NADLLRMASH CPTAADFRDR EITRDTALQA
VSRPGQQRLG QLQKLLAWAD HYKDRLALRV WVEECWLFLG GAASLASDAD LRDTERFLQC
LEELEVDQAP LNGRSLATAV EALYASPGDE RCKVEVMTLH KAKGLEFDWV FIPALAKSTG
GQDKELLLWD EFVLPGAPPS FLLDIRDTAE GGANPRLYDY LKAQAKQKRD YEAARLFYVG
CTRAADYLWL GAALSFSEAK DSYSPPGSGS LLSVIWPSIE HQASVTHVSL DEDAVDAPTL
GYRRLRELPD IAVVAANSPA SPLELSENYL ARALGTAVHR CIEALIYKPE LPECCDEKLR
GLLRVALIEA GADRQALPEL VLEGASMLDR LLGDSWARWA LSAQRRERAA ELPLTIATGT
GAQQLILDYS FLDEEAGERW VIDYKTAIPG PGEDVRQFVM AQLESYGEQL ARYFEALNTR
FDEPVRCALY FPALGRHAEW HPTGAGQ
//
