ID A4ABB6_9GAMM Unreviewed; 573 AA.
AC A4ABB6;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 2.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Thiamine pyrophosphate-requiring enzyme {ECO:0000313|EMBL:EAQ96670.2};
DE EC=2.2.1.6 {ECO:0000313|EMBL:EAQ96670.2};
GN ORFNames=KT71_06584 {ECO:0000313|EMBL:EAQ96670.2};
OS Congregibacter litoralis KT71.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Congregibacter.
OX NCBI_TaxID=314285 {ECO:0000313|EMBL:EAQ96670.2, ECO:0000313|Proteomes:UP000019205};
RN [1] {ECO:0000313|EMBL:EAQ96670.2, ECO:0000313|Proteomes:UP000019205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT71 {ECO:0000313|EMBL:EAQ96670.2,
RC ECO:0000313|Proteomes:UP000019205};
RX PubMed=17299055; DOI=10.1073/pnas.0608046104;
RA Fuchs B.M., Spring S., Teeling H., Quast C., Wulf J., Schattenhofer M.,
RA Yan S., Ferriera S., Johnson J., Glockner F.O., Amann R.;
RT "Characterization of a marine gammaproteobacterium capable of aerobic
RT anoxygenic photosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:2891-2896(2007).
RN [2] {ECO:0000313|EMBL:EAQ96670.2, ECO:0000313|Proteomes:UP000019205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT71 {ECO:0000313|EMBL:EAQ96670.2,
RC ECO:0000313|Proteomes:UP000019205};
RX PubMed=19287491; DOI=10.1371/journal.pone.0004866;
RA Spring S., Lunsdorf H., Fuchs B.M., Tindall B.J.;
RT "The photosynthetic apparatus and its regulation in the aerobic
RT gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.";
RL PLoS ONE 4:E4866-E4866(2009).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ96670.2}.
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DR EMBL; AAOA02000004; EAQ96670.2; -; Genomic_DNA.
DR AlphaFoldDB; A4ABB6; -.
DR STRING; 314285.KT71_06584; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_3_6; -.
DR OrthoDB; 9791859at2; -.
DR Proteomes; UP000019205; Chromosome.
DR GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF166; 2-HYDROXYACYL-COA LYASE 2; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019205};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW Transferase {ECO:0000313|EMBL:EAQ96670.2}.
FT DOMAIN 10..122
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 201..328
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 406..536
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 573 AA; 61677 MW; C38D6B2A2F7B029A CRC64;
MSERPLSRLS GAEAIAKFLK ARRVKRVYGV IGGHIQPICD ALVRIGIDFV DTRHECAAVY
MAHAEARLTG NFGVIMATAG PGVTNAVTGI ANADVARVPV LVISGRVPRP QDGMSSMQDI
PQAEIVRPLC RRVEVVWSAS HILPRLDATV RAAMGSDGAP GPAYIDFATD IQREILPKAD
LNPAWLEPWQ PSVMEPEADQ LDAAAALLRA SRRPLVLAGQ QVHGCCAELE DFLEKTGAIY
LDTTESRGAL PGGHPANVPA MRGNAMKESD VIITLGRKLD FQVAFGSPAI FGADTKFIRV
GRNDDDVSGN RRADAEIKAD VAPVLRQLTN RDIAPSNPDR SWYKEITQRN AERKEGLVNK
IRQLPSHDGI HPYSLIDAVN AHVDEETIAV IDGGDILSFA RVAISDAAAL LDPGALGCIG
VGGAFANAAA LCQPDKKVVA VIGDGSFGFN AMEIHTSSRK DAKVVMVIAN NSGWNIDKHD
QIENYNGNLV GVELGSCRYD QIATAVGAYG ERVEKIEDLP GALERAFKNA PALLDVVVDP
TPQSPDFLSG MAYVHDLQVL GRWHEQEVNW RAE
//