ID   A4ALP3_9ACTN            Unreviewed;       418 AA.
AC   A4ALP3;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=Ribonuclease {ECO:0000313|EMBL:EAR23734.1};
GN   ORFNames=A20C1_03578 {ECO:0000313|EMBL:EAR23734.1};
OS   marine actinobacterium PHSC20C1.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=312284 {ECO:0000313|EMBL:EAR23734.1, ECO:0000313|Proteomes:UP000003868};
RN   [1] {ECO:0000313|EMBL:EAR23734.1, ECO:0000313|Proteomes:UP000003868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHSC20C1 {ECO:0000313|EMBL:EAR23734.1,
RC   ECO:0000313|Proteomes:UP000003868};
RA   Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA   Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAR23734.1}.
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DR   EMBL; AAOB01000016; EAR23734.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4ALP3; -.
DR   STRING; 312284.A20C1_03578; -.
DR   eggNOG; COG0349; Bacteria.
DR   HOGENOM; CLU_042387_3_0_11; -.
DR   OrthoDB; 144122at2; -.
DR   Proteomes; UP000003868; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR041605; Exo_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF18305; DNA_pol_A_exoN; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003868}.
FT   DOMAIN          229..309
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46010 MW;  43400FB1C68245BC CRC64;
     MNSVTESAAS EGESHATQAP HEPVIVIDER EDYLAAVEAI AAGNGPIGID AERASGYRYS
     QRAYLIQIFR RGAGTFLFDP PAIGDFSELN DVIANEEWIL HAATQDLTCL REVGLYPTRL
     FDTELGARIA GLPRVGLGTV VEHFLGIHLA KEHSSADWST RPLPQAWLVY AALDVELLVD
     LREALGELLD SADKHDIAQQ EFDSVLARDL IIVRAEPWRR LSGVHSVRGG KNLAVARELW
     VARDAYAQEV DTAPGRLVPD SALVAAARVL PETKRQLSAL KEFSGRASRT QLDRWWAAIQ
     TGLASTDIPS SRVVNDTLPP PRVWSEKNPE ADRRLKAARA SMMEASEEIS IPIENLLTPD
     YLRRIAWTPP TEISVESISD ALRELGARQW QLDVSAQSIA QAFVEANQTP EDSDDTES
//