ID   A4AMC2_MARSH            Unreviewed;      2007 AA.
AC   A4AMC2;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=FB2170_02635 {ECO:0000313|EMBL:EAR02144.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR02144.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR02144.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the genus
RT   Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; CP002157; EAR02144.1; -; Genomic_DNA.
DR   STRING; 313603.FB2170_02635; -.
DR   KEGG; fbc:FB2170_02635; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_001849_0_0_10; -.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602}.
FT   DOMAIN          955..1095
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1229..1319
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   2007 AA;  230299 MW;  90160CEE2EF1B561 CRC64;
     MAHSQKNNDS YDALWKNVEK LEKEALTKSA LEAVGKISVK AKKENNSVQI VKSLLYTSKY
     ALTLEENAQL NIISDFKDEI AKAEVPTKNV LESYLANLYW QYFQQNRYKF YNRTKTEAKV
     DSVDFRTWDL TTLFEETNLH FQNSLSNPKK LQEIKVDDIR VVLQRQKGSK LYRPTLYDLL
     AHTALDFYKT SENNITRPAN KFEISDPDLI CEYGDFIEQK IDLSDTTSLQ AKALELFHKL
     TDFHIKNNNI EALVEVDIER LKFVHLNAVF NNKDMLFTEV LKNSEQAASK NKTYALYHYE
     IASLKNQLGM GFNPKTNTEN QWYQKEALEL CSAIIKEYPK SKAAQKSKDL TSNILEKSLQ
     LRAEQFIPIN KPSRLLVNYK NHSNLILTAY HLVKEDLQKL DRLYPESKKL AFINKLKVAK
     TWEANLKNES DYQNHSTEVL LPELENGQYI ILATPKAKSN SFAYTNIQIT NLALVETNSR
     THHIFQVIDR NNGAPKKNAK LKISFKEDYD RDFLSKSFTT DANGLVKIPL SNKRWTSVTT
     TITAKDDTAY FGAYYINKKR NNRILHKITY NPFLFTDRSI YRPGQSLYFK GIVVKTENEN
     TSVQAGTKVR VELRDANYQE VKQQELTTNE FGSFTGEFIL PNNGITGNYS LSVSSKEINL
     NGTVDFSVEE YKRPKFETSF DPITETFKVN DSILVDGKAT AYAGSAITDA KVTYRVKRIV
     NYPRWFFWYR PYFNETPQEI AHGETLTDGS GKYEIKFKAI PDNSTKRENL PIFNYEVTAD
     VTDLNGETHS TTTTVRVGYH ALTANISVNG SLEKNKKDNK VTINTQNLNG QFVPAKGTVK
     IYKSVAPQNV LRKRPWEAPD YEGFTKTEFK KLFPHDAFKN EHNSSKWQKG QMVLKKSFDT
     ASSTEIILEN IKKWTSGKYI IELESKDKFG QPVKDMAPMT LYSEKDKTLA DNQLFDIKTN
     KNSYNTGDKV ELTLLSSAEN LNVTLSIEKD RKIIDTQVVH LNNNSKNLTI PVTIDDLGGF
     AVNYTFSAYN SFRSNSLPIA VPYPYTDLEI ETLTFRDKLK PGADETWNFK IKGTKGDKVA
     AELLASMYDA SLDTFRGHYW NFYPIQRQTY YSNFYSNASQ SFGNTSFRVH IDYTYLSIYK
     PQYFDSFDWF GLHFGYGYGL YKERRMMKSA APMAMEVMED SANLDEVVIT ETDMEGNVAG
     VNVLEKAKEE SQKEEDLGDV QIRKNLQETA FFFPQLQTDK EGNVSFSFTT PEALTKWKLQ
     LLAHTKTLQS AMTTLETVTQ KELMVTPNAP RFLREGDKIV ISTKIANLTD KSLSGIAQLE
     LTNVVTGKII SQNLLIADTK DPKDGMASSG RQSFQVDSLG NTQVSWQLKV PADIQAVQYK
     VIAKAGDFSD GEQNVLPVLT NRMLVTETLP MWVRSNQTKT FVLDKLKDNT STTLKHHKLT
     LEITSNPVWY AVQALPYLME YPHDCNEQIF SRYYANTLAS HIANSNPRIQ EVFNQWANSD
     ALLSNLEKNQ ELKSLLIQET PWLRDAQSET EQKKRIALLF NLNKMKNEQA NALNKLNQNQ
     MSSGAWAWFK GGRANRFITQ HIVTGVGHLN KLNVESANHK GHNEMIIKAI AYLDKEFVEE
     YNHMKKHATN LNDDHLSYTQ MHYLYMRSFF QEIKKSKKVN EITAYYEGQT KKYWTKRSLY
     AKGVLALVLH RAKDEKTSKK ILRSLKENSI VSEEMGMYWK ANTNSWFWHQ APIETQALMI
     EAFAEIENDN TTIDNLKIWL LKNKQTNQWK TTKATTEAIY ALLLQGNDWL SVTDAVDVLV
     GGEKIEPSKL EDVKVEAGTG YYKTSWSKKE IEPQQAEVQL TKKGNGIAWG AMYWQYFEDL
     DKITSAETPL KLKKKLFLKQ YTDTGEEIKE INDETKLKVG DLIRIRIELR ADRPMEFVHM
     KDMRASGLEP VNVLSRYKWQ DGLGYYESTK DASTNFFFDY LPKGVFVFEY DLRVNNAGDF
     SNGITTIQSM YAPEFSSHSE GIRIEIE
//