ID A4ASM6_MARSH Unreviewed; 734 AA.
AC A4ASM6;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:EAR00961.1};
GN OrderedLocusNames=FB2170_09326 {ECO:0000313|EMBL:EAR00961.1};
OS Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Maribacter.
OX NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00961.1, ECO:0000313|Proteomes:UP000001602};
RN [1] {ECO:0000313|EMBL:EAR00961.1, ECO:0000313|Proteomes:UP000001602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX PubMed=21037013; DOI=10.1128/JB.01207-10;
RA Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA Cho J.C.;
RT "Complete genome sequence of strain HTCC2170, a novel member of the genus
RT Maribacter in the family Flavobacteriaceae.";
RL J. Bacteriol. 193:303-304(2011).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CP002157; EAR00961.1; -; Genomic_DNA.
DR RefSeq; WP_013306513.1; NC_014472.1.
DR AlphaFoldDB; A4ASM6; -.
DR STRING; 313603.FB2170_09326; -.
DR KEGG; fbc:FB2170_09326; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_2_10; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000001602; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EAR00961.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001602};
KW Transferase {ECO:0000313|EMBL:EAR00961.1}.
FT DOMAIN 402..463
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 734 AA; 83951 MW; 0FF5D23DEA138C6B CRC64;
MTQAAIEKEN KQIAKQYKEL LRISYQTLSN DDKILIRQAF EIAVDAHKEQ RRKSGEAYIF
HPIAVAKIVA SEIGLDAVSI ASALLHDVVE DTSYTLDDIE RMFGETVARI VDGLTKIAHL
KKDMNISQQA ENFRKMLLTL HDDVRVIIIK IADRYHNMLT LDAMPEHKQV KMASETLYIY
APLAHRIGLY NIKTELEDLS LKYTEPEVYQ DINSKIEVST EEQQDYIDDF TSIIRDSLDK
EGLNYNIKGR MKSIFSIRKK MKVQNVSFDQ IYDKFAIRII YKSDKANEKF LAWKIYSIVT
DHFTPNPVRL RDWISSPKST GYEALHITVM GPKGKWVEVQ IRSERMHEIA EKGYAAHFKY
KHGNQKEQGI EVWLNKLQEA LENSNTSAVD FVEEFKLNLY SKEIFVFTPL GELKSMPKGA
TPLDFAFNIH TEVGMRTRGA KVNGKLVPLN TSLKSGDQVE IITSEQAKPN QNWLDYATTA
RARAKIKSSL REEKKSIAED GKEILRRKLK SQKINLNEDT INKMVIFFKL KTSLDLFYRV
GSGAIDNQKI KDFASSYNNA FISFFKSKIR RKTIPEGIDK EEITAKYDML VFGKEEEKLD
YKLSQCCNPI PGDDVFGFVS VNEGIKVHKK NCPNAISLQS NYAYRIISAK WIDSSQQEFK
SEIQLTGIDN LGLISEITEV ISNHMSVNIR NLNFSTDSGT FVGRITVVVK NNLILKKLIA
NLKQINGIDK VTRV
//
