ID A4BKA8_9GAMM Unreviewed; 481 AA.
AC A4BKA8;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 08-NOV-2023, entry version 64.
DE SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:EAR07413.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:EAR07413.1};
GN Name=cls {ECO:0000313|EMBL:EAR07413.1};
GN ORFNames=MED297_18977 {ECO:0000313|EMBL:EAR07413.1};
OS Reinekea blandensis MED297.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Saccharospirillaceae; Reinekea.
OX NCBI_TaxID=314283 {ECO:0000313|EMBL:EAR07413.1, ECO:0000313|Proteomes:UP000005953};
RN [1] {ECO:0000313|EMBL:EAR07413.1, ECO:0000313|Proteomes:UP000005953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED297 {ECO:0000313|EMBL:EAR07413.1,
RC ECO:0000313|Proteomes:UP000005953};
RA Pinhassi J., Pedros-Alio C., Ferriera S., Johnson J., Kravitz S.,
RA Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R.,
RA Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR07413.1}.
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DR EMBL; AAOE01000043; EAR07413.1; -; Genomic_DNA.
DR RefSeq; WP_008044364.1; NZ_CH724151.1.
DR AlphaFoldDB; A4BKA8; -.
DR STRING; 314283.MED297_18977; -.
DR HOGENOM; CLU_038053_1_0_6; -.
DR OrthoDB; 9762009at2; -.
DR Proteomes; UP000005953; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09152; PLDc_EcCLS_like_1; 1.
DR CDD; cd09158; PLDc_EcCLS_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000005953};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EAR07413.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..243
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 394..421
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 481 AA; 54832 MW; 5F0CA461509B8B11 CRC64;
MNWQWLITIG LWLYGISLIA LTLRILMKRR PVGVSLAWLL FLYIIPVGGI VAYLLFGERY
LGRLRARRAT EQFNYYSLWL QRILLEQQHV SPARPVLRPV MELTRGSLGM PVIVGSRWSL
HSDPQDVFKR LIDDIDNANE TILMEFYILE AEGAVLPVLD ALEQAVSRGI QVYLMVDSVG
SNRFLRSKRS RQLTEAGVKV VDALHANLLR MTLRRQDLRQ HRKLIAIDNQ IAYTGSMNLA
DPAHFKTSSG VGPWVDIMVR LEGDIAKVIQ GTLIFDWEME TGIRLEKHLD WPEFKPVKDD
NLMQLLPSGP ALDEEILLQV LLTVIHNARS SITITTPYFV PDEALLQALK SAAKRGLEVT
VILPAKNDSR LAEYAGRSFY YELLQAGVHL LQFNGGLLHT KTVVIDRHMV LIGSVNLDMR
SIWLNFESTL IVDDDDFCEA VLAQIDVYQN ESHCLLSYEW QKRPHHQRLL ENLAQLASPL
L
//
