ID   A4BL21_9GAMM            Unreviewed;       850 AA.
AC   A4BL21;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=NB231_14353 {ECO:0000313|EMBL:EAR23009.1};
OS   Nitrococcus mobilis Nb-231.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Nitrococcus.
OX   NCBI_TaxID=314278 {ECO:0000313|EMBL:EAR23009.1, ECO:0000313|Proteomes:UP000003374};
RN   [1] {ECO:0000313|EMBL:EAR23009.1, ECO:0000313|Proteomes:UP000003374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nb-231 {ECO:0000313|EMBL:EAR23009.1,
RC   ECO:0000313|Proteomes:UP000003374};
RA   Waterbury J., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA   Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAR23009.1}.
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DR   EMBL; AAOF01000001; EAR23009.1; -; Genomic_DNA.
DR   RefSeq; WP_005003830.1; NZ_CH672427.1.
DR   AlphaFoldDB; A4BL21; -.
DR   STRING; 314278.NB231_14353; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_009504_0_0_6; -.
DR   OrthoDB; 7066673at2; -.
DR   Proteomes; UP000003374; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000003374}.
FT   DOMAIN          264..558
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         285..292
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   850 AA;  97108 MW;  BFCC3770EF523001 CRC64;
     MNVLEYKNYR KSLTALRRRG GRFQKAAEKA IVYQDDLKDE RLRKKLPVTN HGENRIDKAV
     KYDLGGNGCR LVTVQDNGRI FLCFAGAHDD VDKWLDKNRG LTIRVDEGNR VIPSFESKDY
     TNPEERLQRD AGYTDKPLVS LLQQRHQDAI MKGLAWSLAK AIGEATVEVS DDEIQQLVDR
     IEDLVQQTAV FDALMLLREE NIDGATNRIR AFTGELCKLG DQEQSLPYLE DSEYFQNVDV
     SSEHYQKLIE NFARNADYKD WMLFMRPAQQ RFVDADYAGP AKVTGVSGSG KTAVVVRRAI
     ALTERYPDQQ VLVLTLNRSL AVLIEELVNT AALEEVRDRI EVLPFFMLCQ RFLYQFEPDN
     TRLYDDVTWK SREHIDAIWR EYYRCELHNY DARALQKVHD SLISRGIDAE SYIREEFDWI
     RSATAPGNRD AYLSMERTGR TYPLDANFRQ DLLRGLESWE RKMTFVGVTD YLGIANALYH
     HIDKIEPRYR CVLVDESQDF GTIDFQLIRR LVAEDSNDVF LCGDAAQKVS SKHHSLSDAG
     LAVAGSRSHK LVLNYRNSRQ ILELAHGMLM DNLFNEMLQI HDFEILDPEY ANFGGPTPLF
     LSAASLGDEL AAAVTYAKSE AEENSAAKIC IAICGFSEHE LEAFAQNQRL PLLNGETDLK
     GHQVIVSDLE NTKGFEFHCM IIVNCADGVV PNPRAPVEEA FRDLSRLYVA MTRARHQLVL
     SCCGAPSPFL EGQLKHLSQY LWEEYIGQEQ DLAPLEPPKR LEQLRHDTPP RDILSMTGEE
     YLYQEDAIGC PALLVEKLRK LVTGKSRIVQ GTPAEWRSIS AALKDTRSKP RCRQLFGPEG
     YRVFREWFDN
//