ID A4C994_9GAMM Unreviewed; 269 AA.
AC A4C994;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=bis(5'-nucleosyl)-tetraphosphatase (symmetrical) {ECO:0000256|ARBA:ARBA00012506};
DE EC=3.6.1.41 {ECO:0000256|ARBA:ARBA00012506};
DE AltName: Full=Ap4A hydrolase {ECO:0000256|ARBA:ARBA00032248};
DE AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00031248};
DE AltName: Full=Diadenosine tetraphosphatase {ECO:0000256|ARBA:ARBA00033210};
GN ORFNames=PTD2_08944 {ECO:0000313|EMBL:EAR29159.1};
OS Pseudoalteromonas tunicata D2.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=87626 {ECO:0000313|EMBL:EAR29159.1, ECO:0000313|Proteomes:UP000006201};
RN [1] {ECO:0000313|EMBL:EAR29159.1, ECO:0000313|Proteomes:UP000006201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D2 {ECO:0000313|EMBL:EAR29159.1,
RC ECO:0000313|Proteomes:UP000006201};
RA Moran M.A., Kjelleberg S., Egan S., Saunders N., Thomas T., Ferriera S.,
RA Johnson J., Kravitz S., Halpern A., Remington K., Beeson K., Tran B.,
RA Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield
CC ADP. {ECO:0000256|ARBA:ARBA00003413}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2
CC H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58141, ChEBI:CHEBI:456216; EC=3.6.1.41;
CC Evidence={ECO:0000256|ARBA:ARBA00001682};
CC -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC {ECO:0000256|ARBA:ARBA00005419}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR29159.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAOH01000003; EAR29159.1; -; Genomic_DNA.
DR RefSeq; WP_009838420.1; NZ_AAOH01000003.1.
DR AlphaFoldDB; A4C994; -.
DR STRING; 87626.PTD2_08944; -.
DR eggNOG; COG0639; Bacteria.
DR HOGENOM; CLU_056184_2_0_6; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000006201; Unassembled WGS sequence.
DR GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-EC.
DR CDD; cd07422; MPP_ApaH; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004617; ApaH.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR NCBIfam; TIGR00668; apaH; 1.
DR PANTHER; PTHR42850:SF11; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [SYMMETRICAL]; 1.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAR29159.1}.
FT DOMAIN 4..145
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 269 AA; 30171 MW; 80452E1AF2FECEF4 CRC64;
MAQYVIGDLQ GCFKEFKAIL ATLAFNPSQD TLYLVGDIVA RGPDSLSCLR FIKDNASSVK
TTLGNHDLHL ISTFLLNKQP NPKDLLADIF TAPDRNELIE YLQARPLALF LPEFNSLVCH
AGLSPEWTLA QALKAAKIAE QAYQGKDARY YLANMYQNGP TRWQDAKTEI EKFCYTINAF
TRMRYFTSDF KMDLSSKGSP AQDSPLIPWF ELPRASSLND LTVIFGHWAA LEGKTNSNQF
QAIDTGCVWG QALTALNLET QQRTQQKSL
//
