ID   A4D4D6_9INFB            Unreviewed;       751 AA.
AC   A4D4D6;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-NOV-2023, entry version 57.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:ABL76802.1};
OS   Influenza B virus (B/Romania/217/1999).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Betainfluenzavirus;
OC   Betainfluenzavirus influenzae; Influenza B virus.
OX   NCBI_TaxID=408930 {ECO:0000313|EMBL:ABL76802.1};
RN   [1] {ECO:0000313|EMBL:ABL76802.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Influenza B virus {ECO:0000313|EMBL:ABL76802.1};
RA   Spiro D., Sengamalay N., Boyne A., Bera J., Halpin R., Wang S., Ghedin E.,
RA   Zaborsky J., Subbu V., Sparenborg J., Gallagher T., Overton L., Althoff R.,
RA   Liu X., Salzberg S.L., Sitz J., Katzel D., Neupane R., Shumway M., Koo H.,
RA   Griesemer S., StGeorge K., Bennett R., Taylor J., Klimov A., Hall H.,
RA   Balish A., Xu X., Shaw M., Cox N., Bao Y., Bolotov P., Dernovoy D.,
RA   Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID Influenza Genome Sequencing Project.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABL76802.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Influenza B virus {ECO:0000313|EMBL:ABL76802.1};
RG   The NIAID Influenza Genome Sequencing Consortium;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CY018427; ABL76802.1; -; Viral_cRNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 6.10.140.720; -; 1.
DR   HAMAP; MF_04065; INFV_RDRP; 1.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU004330};
KW   Transferase {ECO:0000256|ARBA:ARBA00022695};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          285..481
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABL76802.1"
SQ   SEQUENCE   751 AA;  84113 MW;  2D46E2E9F3B6D906 CRC64;
     DINPYFLFID VPIQAAISTT FPYTGVPPYS HGTGTGHTID TVIRTHEYSN KGKQYVSDIT
     GCTMVDPTNG PLPEDNEPSA YAQLDCVLEA LDRMDEEHPG LFQAASQNAM EALMVTTVDK
     LTQGRQTFDW TVCRNQPAAT ALNTTITSFR LNDLNGADKG GLVPFCQDII DSLDKPEMTF
     FSVKNIKKKL PAKNRKGFLI KRIPMKVKDR ISRVEYIKRA LSLNTMTKDA ERGKLKRRAI
     ATAGIQIRGF VLVVENLAKN ICENLEQSGL PVGGNEKKAK LSNAVAKMLS NCPPGGISMT
     VTGDNTKWNE CLNPRVFLAM TERITRDSPI WFRDFCSIAP VLFSNKIARL GKGFMITSKT
     KRLKAQIPCP DLFSIPLERY NEETRAKLKK LKPFFNEEGT ASLSPGMMMG MFNMLSTVLG
     VAALGIKNIG NKEYLWDGLQ SSDDFALFVN AKDEETCMEG INDFYRTCKL LGINMSKKKS
     YCNETGMFEF TSMFYRDGFV SNFAMEIPSF GVAGVNESAD MAIGMTIIKN NMINNGMGPA
     TAQTAIQLFI ADYRYTYKCH RGDSKVEGKR MKIIKELWEN TKGRDGLLVA DGGPNIYNLR
     NLHIPEIVLK YNLMDPEYKG RLLHPQNPFV GHLSIEGIKE ADITPAHGPV KKMDYDAVSG
     THSWRTKRNR SILNTDQRNM ILEEQCYAKC CNLFEACFNS ASYRKPVGQH SMLEAMAHRL
     RMDARLDYES GRMSKDDFEK AMAHLGEIGY T
//