ID A4ERW9_9RHOB Unreviewed; 990 AA.
AC A4ERW9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Sarcosine oxidase alpha subunit {ECO:0000313|EMBL:EBA18025.1};
GN ORFNames=RSK20926_19842 {ECO:0000313|EMBL:EBA18025.1};
OS Roseobacter sp. SK209-2-6.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseobacter.
OX NCBI_TaxID=388739 {ECO:0000313|EMBL:EBA18025.1, ECO:0000313|Proteomes:UP000005964};
RN [1] {ECO:0000313|EMBL:EBA18025.1, ECO:0000313|Proteomes:UP000005964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK209-2-6 {ECO:0000313|EMBL:EBA18025.1,
RC ECO:0000313|Proteomes:UP000005964};
RA Ward B., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EBA18025.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAYC01000002; EBA18025.1; -; Genomic_DNA.
DR RefSeq; WP_008204923.1; NZ_AAYC01000002.1.
DR AlphaFoldDB; A4ERW9; -.
DR eggNOG; COG0404; Bacteria.
DR eggNOG; COG0446; Bacteria.
DR OrthoDB; 5287468at2; -.
DR Proteomes; UP000005964; Unassembled WGS sequence.
DR GO; GO:0008115; F:sarcosine oxidase activity; IEA:InterPro.
DR GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
DR Gene3D; 3.10.20.440; 2Fe-2S iron-sulphur cluster binding domain, sarcosine oxidase, alpha subunit, N-terminal domain; 1.
DR Gene3D; 1.10.10.1100; BFD-like [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR042204; 2Fe-2S-bd_N.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR006277; Sarcosine_oxidase_asu.
DR InterPro; IPR041117; SoxA_A3.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR NCBIfam; TIGR01372; soxA; 1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF17806; SO_alpha_A3; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005964}.
FT DOMAIN 177..430
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 507..590
FT /note="SoxA A3"
FT /evidence="ECO:0000259|Pfam:PF17806"
FT DOMAIN 605..871
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 897..982
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 990 AA; 106546 MW; A7E1915255688F08 CRC64;
MSATRMSKGG RIDRSCPLRF TWDGRAYQGF AGDTLASALM ANGEVVLGRS FKYHRPRGIM
SAGVEESGAI VTLGTGNRAE PNTKATMVEL YDGLVASGQN AWPNVRSDIG AALGLFGRFF
SAGFYYKTFM GLPPFEWGRG TGLWMQYEKL IRKAAGMGAA SREADPDCYD HMHGFCDVLV
VGSGPAGLNA ALRAAQQGKD VILVEQDHEL GGDLLNQADP TAETTRADLI AALEAAGVRI
MTRTTAFGLY DYGTAGLLQR VSDHLAVKPE HSPRQRFWTV RSAATILATG ALERTVAFEN
NDRPGVMTAN AARSYLNRYG VLPGQNIVLS TNNDSAYGVA VELAQAGAKV TLVELRAKVS
PELAKQMRVA GVQIKTGLAP LKAIGDKAVS AVRLARPHGE AWRVAETLRC DLLLVSAGWS
PVVNLLSHRG AKPLWDQSLA CFLPAPSVEN VTIAGSAAGH WSAEECVASG IAAADQALGL
PVKEPVRAGW ETPIKPLYEV RLPGKKTKSF VDPQHDVTAS DVRLAHQEGF VSVEHLKRYT
TLGMATDQGK MGNVIGLALM AEALGKEIPA VGTTRFRPPY TPVAIGALAG RNTGSHFKVL
RRTPLHDWNL RHGATMTDAG LWHRPWYFGR TGESITEAYI REATTVRQTL GICDVSSLGK
IAVQGPDASE FLNRIYSNAF AKLAVGKARY GIMLRDDGMV MDDGTTWRLS ENDFLLTTTT
TGAGKVMVWL EELLQLRWPE LEVHVTSVSD QWAGVSVAGP KSRAAIAACL TDPEMISAES
LPFMGVRETR LKSGIKCLIA RISFSGELAY ELYVPANQGE AMMDLLWAAS EPLGGCLYGL
EALGTLRIEK GHVTGAELDG RVTIDDAGLG KMASTKKSFI GSVLRKRPEL ERADRPQLVG
IFPKDRSESF NGGALLCKPD EISGFGEGWI TAVTHSPTLG HWIGLGYISG GHDAWQGRAV
TATDPVRKGD VAVEIVTPHM FDPKGERMHG
//
