ID   A4F6U5_SACEN            Unreviewed;      1041 AA.
AC   A4F6U5;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=Putative ATPase {ECO:0000313|EMBL:PFG93571.1};
DE   SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:CAL99769.1};
GN   OrderedLocusNames=SACE_0421 {ECO:0000313|EMBL:CAL99769.1};
GN   ORFNames=A8924_0818 {ECO:0000313|EMBL:PFG93571.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99769.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAL99769.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAL99769.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG93571.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93571.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
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DR   EMBL; AM420293; CAL99769.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG93571.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4F6U5; -.
DR   STRING; 405948.SACE_0421; -.
DR   KEGG; sen:SACE_0421; -.
DR   eggNOG; COG3629; Bacteria.
DR   eggNOG; COG3903; Bacteria.
DR   HOGENOM; CLU_004665_1_3_11; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN          1..87
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51755"
FT   DNA_BIND        1..87
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   1041 AA;  112834 MW;  B393F802023856AC CRC64;
     MLGPFRLCAA DGHPIDVGGA RVRMLLARLA LDAGRTVATE TLIDDLWGAN QPSGALNALQ
     SLVSRARRAL PDDLVLQSAA TGYALKADAA DVDAHRFARL AADGRGLLRD GRFAAAARTL
     REALRLWRGG ALVDFVDAPF AAAQAARLEE LRLGALEDRI DADLRAGRDG EPVELVELVA
     ELDGLCARHP LRERFTGLRM RALYSAGRQA DALGAYEALR RRLADELGVD PSQELRDLHG
     AVLRGEPREH RDRPPVLPSR LSSFVGREAE IEQVRTAMAR SKLVTLFGPG GAGKTRLATE
     TAAGVDDRRV WFVELASVRQ GEDLPSAVLA SVGVRETRLL DTAPADAMTR LVDGLSGAPA
     LLVLDNCEHV IGAAAQFVQD LLTWCPQLGV LATSREPLAL TGEELLPVGP LGLPDGEAPL
     EADAVRLFAD RARSARPGFV LDDATIGDVV EVCRRLDGMP LAIELAAARL RAMSVRQVAA
     RLDDRFRLLT SGNRASLARH RTLRAVVEWS WDLLGEPERL LARRLSVFAG PARAESAAAV
     CSDARLPAED VFYVLSSLVE KSFVEAVDGD RYRMLETVRA YCDDRLAESG ERDRVRTAHA
     EHFVELAETA SPRLHRVEQV EWLERLDADH DNLMTALRWA ISSQNADLGV RMGAALAWYW
     SMSAHGELAS RLEALTPIPG DAPSEGRAVL EFIQAMLCQT TSWTERIGAA AARLRDTGAG
     RRYLYVTIME PMAWMFVGDR AEMDAAVRRN LEHPDPWGRA AALFSRAFGA EHGGDAAGGE
     EHMRAAARAF REQGDRWGIA QSMGSLAGFR SLRGDHAGAI EALEESAETL RELRSDEEVA
     PTMVRIGMEH VRAGDIAEGR RCLEQADELA AASFAEFARL GSLTALGEAA RRAGDVERAR
     AYFAQARELL AGTPMAPPPL HQVALATEAR VDIDELRLDD ARARLRESLD SSGEIPMMPT
     IAMIAEQTAL LRFAAGDHRQ ASYLLGVAVA LRGMLDEGDP DIRAVLPALD APDLRSERDR
     GAALTHEAAL AVLREVLGPR G
//