ID A4F7H2_SACEN Unreviewed; 383 AA.
AC A4F7H2;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Glucosyltransferase {ECO:0000313|EMBL:CAL99996.1};
DE EC=2.4.1.- {ECO:0000313|EMBL:CAL99996.1};
DE SubName: Full=L-noviosyl transferase {ECO:0000313|EMBL:PFG93798.1};
GN Name=iroB {ECO:0000313|EMBL:CAL99996.1};
GN OrderedLocusNames=SACE_0652 {ECO:0000313|EMBL:CAL99996.1};
GN ORFNames=A8924_1050 {ECO:0000313|EMBL:PFG93798.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99996.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAL99996.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAL99996.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG93798.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93798.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC {ECO:0000256|ARBA:ARBA00006962}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM420293; CAL99996.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG93798.1; -; Genomic_DNA.
DR RefSeq; WP_009950020.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F7H2; -.
DR STRING; 405948.SACE_0652; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR KEGG; sen:SACE_0652; -.
DR eggNOG; COG1819; Bacteria.
DR HOGENOM; CLU_000537_7_4_11; -.
DR OrthoDB; 5488434at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProt.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR010610; EryCIII-like_C.
DR InterPro; IPR048284; EryCIII-like_N.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48050; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR48050:SF13; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF06722; EryCIII-like_C; 1.
DR Pfam; PF21036; EryCIII-like_N; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:CAL99996.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAL99996.1}.
FT DOMAIN 22..64
FT /note="Erythromycin biosynthesis protein CIII-like N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21036"
FT DOMAIN 101..225
FT /note="Erythromycin biosynthesis protein CIII-like N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21036"
FT DOMAIN 239..374
FT /note="Erythromycin biosynthesis protein CIII-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06722"
SQ SEQUENCE 383 AA; 40979 MW; DD8CA1C639F29F34 CRC64;
MRVLLSSLPA AGHLYPLVPF AWALRCAGHD VLVAAPSDLV PEATATGLPV AAVTDGPIGL
RDLLERLRRL PWFGGDHAIL GSLHDFATGA DDRSPLTDLV EQTLPGTEAL VRDWRPDVVL
RDMADLTGVL ACARTGVPFA EHWWGLAAPA PARGELRRIF GDLFARFEAR TPPRRALTID
PVPPSFQSDD APPVYRSRYV PYNGRAERPA LPPRSQTPRI CLSFGTLLTG DGVSGLAERV
LDAAHRLGAE VVLAADEPPV ESHPALLAAG RLPLDQVLAS CDALVHHGGS GTMLTALCHG
LPQLVFPHGS DHFVNADRLR SLHLAAVLNA RDDPTRVERT LHAVLTDEGM RAGTRKIADE
IAAQPAPADL VPLFEATVED LAA
//
