ID A4FAH5_SACEN Unreviewed; 615 AA.
AC A4FAH5;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Hsp70 protein {ECO:0000313|EMBL:PFG94837.1};
GN OrderedLocusNames=SACE_1732 {ECO:0000313|EMBL:CAM01050.1};
GN ORFNames=A8924_2137 {ECO:0000313|EMBL:PFG94837.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM01050.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM01050.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM01050.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG94837.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG94837.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; AM420293; CAM01050.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG94837.1; -; Genomic_DNA.
DR RefSeq; WP_009943802.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FAH5; -.
DR STRING; 405948.SACE_1732; -.
DR KEGG; sen:SACE_1732; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_443232_0_0_11; -.
DR OrthoDB; 3333926at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10170; HSP70_NBD; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 397..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 65414 MW; 85BAEBD6D6AA89B3 CRC64;
MRVLSVDLGT SNTVAVLSAH GRPPRVVEVD GSATMPSAVF AAEDGAIIVG REAERRARLD
PSRFEPNPKR RVDEGTLLLG ESIITVTDAM AAVLHRVAEE TTRQLGGAQP DEVRLTHPAQ
WGPTRRNVLL SAARLAGFGS NLVLVPEPVA AAAHFASFPD RSLAPGQALA VYDLGAGTFD
CAVVGATQSG FAVLAEDGLP DLGGLDVDQA LLEHVGRQVS NKDPQRWQRL LRPESTADRR
AQRALREDVK AAKEALSRHV QTEVPMPEPF EDVLVTRGEL EALVRPSMLR SVEMVASVVR
SNGMAPENLA GLYLVGGSSR LPLVATLIGE QLRIVATSLD QPETAVALGA HHVSRDGTAL
NTQDLGSTFT AAQQGVGDQG PRPGYQEPET VRTAFAPVMP PQQPYPRQVR QQGHGAKQPR
TVSRNMLVGL GAVALVAVIV AVVSIVLTSG GGAQAASASE CRAPSETRDT KGFDKCMLQL
AGDVPETTNC APGWQRIMPG LRELGGAVAS CSIGNPNEGT TIVYTHLDSM QKAKQRADLL
LEFNGVTSDQ VRADWSGNGL SGEYRAVTSD TFGTLVFTVD DRPLVGMVLV PNKDQRLAPN
QVADEFERRI QPGTD
//
