ID A4FB66_SACEN Unreviewed; 777 AA.
AC A4FB66;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Non-specific serine/threonine protein kinase {ECO:0000313|EMBL:PFG95073.1};
DE SubName: Full=Protein kinase/transcriptional regulator, LuxR family {ECO:0000313|EMBL:CAM01291.1};
DE EC=2.7.11.1 {ECO:0000313|EMBL:CAM01291.1};
GN OrderedLocusNames=SACE_1981 {ECO:0000313|EMBL:CAM01291.1};
GN ORFNames=A8924_2384 {ECO:0000313|EMBL:PFG95073.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM01291.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM01291.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM01291.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG95073.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG95073.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM01291.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG95073.1; -; Genomic_DNA.
DR RefSeq; WP_009942522.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FB66; -.
DR STRING; 405948.SACE_1981; -.
DR KEGG; sen:SACE_1981; -.
DR eggNOG; COG2197; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR HOGENOM; CLU_004665_5_3_11; -.
DR OrthoDB; 9812579at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000313|EMBL:CAM01291.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:PFG95073.1};
KW Transferase {ECO:0000313|EMBL:CAM01291.1}.
FT DOMAIN 707..772
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
SQ SEQUENCE 777 AA; 85583 MW; E3F69718931AC182 CRC64;
MARTTTERRS AGNLPAGTTS FVGRRHELTE VKRLLSVYRL VTLTGPGGVG KTRLSMRVAA
DVRRAFHDQA WFVDLGELRE PNLVPQTVAE QLEIHEQSSR PVQDAVVERL GAGPTLLVLD
SCEHLVDACA ALVNTLIQVC PELRVVATSR QSLGLVGECT YTVPPFEVPD PEHAGSPNAV
AHFDSVRLFV ARAAAVLPSF EVDQSNYQAL ARICHDLDGI PLAIELTAVR LRSLSLEQIA
DRLTEQHRLL GEATRGLPPR QRTLRALIDW SYELCSAPER LVWARASVFS GSFDLDAVEH
VASGDGVAEA DVLGLVDALV DKSIFLRDSG QAVARYRMLD TTRAYGVEKL AAGGGHEAAR
RRHRDYFAGL TRRFAAEWLG PDEPAWINRL WLEHPNLRVA FDYCARQEGE AEAGLRMVVQ
LADFLSLRGY HTETRMWLDR LLASATEPSH ERLSSLMLDA WFALQQGDAG TARSSLGESE
DLAARIGSSE ELAYLAHLRG MEALVEADVD RADPLFGEAY ERFRTAGSLR GEMLTLFLYG
LTVGHRGQAE KGRMLLDACI DKSVRLGDTF WRSHALWAHA YVDVAAGEPE RAERSCKESL
RLGRLLADRT AMAFSLETLA WVEATLGRHG RAATLFGLAA SVWESLGGSP EFYSSFAHAH
HAHVAGVREA LGDSAYEQAF EQGHRLSAAQ AVDFALETER PRDARQPTGE QPLLTRREFQ
IAELVAEGLT NRDIAARLVI STRTAEGHVE NILTKLGFSS RTQIAAWVTA RQESAQR
//
