ID A4FCM0_SACEN Unreviewed; 728 AA.
AC A4FCM0;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Integral membrane protein, MmpL family {ECO:0000313|EMBL:CAM01795.1};
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:PFG95559.1};
GN OrderedLocusNames=SACE_2502 {ECO:0000313|EMBL:CAM01795.1};
GN ORFNames=A8924_2894 {ECO:0000313|EMBL:PFG95559.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM01795.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM01795.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM01795.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG95559.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG95559.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; AM420293; CAM01795.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG95559.1; -; Genomic_DNA.
DR RefSeq; WP_009947235.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FCM0; -.
DR STRING; 405948.SACE_2502; -.
DR KEGG; sen:SACE_2502; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_4_1_11; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..379
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 484..719
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 728 AA; 75964 MW; 62834CE711828B9F CRC64;
MAGGRSWANR YAAVVVRGRW LVLAGVAGLV YAVMSFLPPL GHGSGGLAGV VGTESEAISA
QIEAVQRFRM PLLTRVAVVQ HDPDGLNPYA QARVVLRALA VNKESLQGTT TSGVRLALPV
INRPELGAGG GAATTAVTYL FTDPAADFGK QTEAAHQYAS DIDRPGDHLV GVTGTAPLQA
EQTTIVRNNV RWVEIGSVAV VALIVGVTFR SVLAPAVTLL TAAVTYLLTA RVVGAGAELT
GFSAPAQLEP VLVALSLGVA TDYSIFFLAG MQRGLAHGDD RHTAARATTV EYLPIVLVAG
ATVAGGVLAL VAAETTMFRA FGPGLAVTVL MALLISVTLV PALLAVLGRA VFWPLPPRPG
GDGQDDDAGR MVRLLTRRWV AAFVAVAITA LLVLAALPLR DLRESFSPMT SLPRDNPVRV
AWQAAADGFG PGVLSPTEII LNRPGIASDA GPLSALQSEI GRQPGVARVL GPQDFTLPPQ
LRQEAGLFLA PDGGAARYLA VLDADPLGAE AVADLRRLEG RMPELLAASD LGGASVSYAG
DTALGLSLVE STRPDVVRVA VVIALVDLLL LVLFLRAVVA PLYLLAASFL SLAAVLGLTT
LFFEHATEEQ GIVFFVPFAA GALLISLGSD YSIFSVGYVR AESRNRPMRE ALVVAIPRSR
RAITAAGLAL AASFGLVALV PLAQFRELAF ALGVGVVLDV FVVRSWLVPA LMTLEAGRKL
EENAEKDH
//
