ID A4FE77_SACEN Unreviewed; 393 AA.
AC A4FE77;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Hydrogenase expression/formation protein HypE {ECO:0000313|EMBL:CAM02352.1};
DE EC=2.7.4.16 {ECO:0000313|EMBL:CAM02352.1};
DE SubName: Full=Hydrogenase maturation carbamoyl dehydratase HypE {ECO:0000313|EMBL:PFG96079.1};
GN OrderedLocusNames=SACE_3074 {ECO:0000313|EMBL:CAM02352.1};
GN ORFNames=A8924_3467 {ECO:0000313|EMBL:PFG96079.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02352.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02352.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM02352.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG96079.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96079.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HypE family.
CC {ECO:0000256|ARBA:ARBA00006243}.
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DR EMBL; AM420293; CAM02352.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG96079.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FE77; -.
DR STRING; 405948.SACE_3074; -.
DR KEGG; sen:SACE_3074; -.
DR eggNOG; COG0309; Bacteria.
DR HOGENOM; CLU_049733_0_0_11; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0009030; F:thiamine-phosphate kinase activity; IEA:UniProtKB-EC.
DR CDD; cd02197; HypE; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR InterPro; IPR011854; HypE.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR016188; PurM-like_N.
DR InterPro; IPR036921; PurM-like_N_sf.
DR NCBIfam; TIGR02124; hypE; 1.
DR PANTHER; PTHR30303:SF0; CARBAMOYL DEHYDRATASE HYPE; 1.
DR PANTHER; PTHR30303; HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE; 1.
DR Pfam; PF00586; AIRS; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAM02352.1}.
FT DOMAIN 96..207
FT /note="PurM-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00586"
FT DOMAIN 219..365
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 40618 MW; 0D6BE39C2B3A79AA CRC64;
MSSDQDATAG VEPGRTPGWV ADAMVHHERE GQPGSGHATR EEQVLERIDR ARRRKAKVKE
DRVTLAHGSG GKATQTLVEA IFLESFRNPL LERMEDGAEL AVNGSRLAFT TDSFVVSPLF
FPGGDIGDLA VNGTVNDLAV SGATPLYLSA GFIIEEGFPV AELTRIVESM SAAAARAGVQ
VVTGDTKVVQ KGKADGCYVN TAGVGLIETG HRLGADTARP GDAVLVSGPI GDHGVTVMLE
RGELDIDADI TSDTAAVNGM VAGLLAAVPG VRAMRDATRG GVATVLNEIA RASDVSVVVD
EAEVPVRTEV RGACELLGID PLYVACEGRI VVVVDGAQAE TALAALRSHP LGGGAALIGR
IGDDPPGLVL LNTAFGGTRI VDLLVGDPLP RIC
//
