ID A4FFA9_SACEN Unreviewed; 345 AA.
AC A4FFA9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:CAM02734.1};
DE EC=1.1.1.262 {ECO:0000313|EMBL:CAM02734.1};
GN Name=pdxA {ECO:0000313|EMBL:CAM02734.1};
GN OrderedLocusNames=SACE_3460 {ECO:0000313|EMBL:CAM02734.1};
GN ORFNames=A8924_3853 {ECO:0000313|EMBL:PFG96457.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02734.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02734.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM02734.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG96457.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96457.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM02734.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG96457.1; -; Genomic_DNA.
DR RefSeq; WP_009942279.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FFA9; -.
DR STRING; 405948.SACE_3460; -.
DR KEGG; sen:SACE_3460; -.
DR eggNOG; COG1995; Bacteria.
DR HOGENOM; CLU_040168_0_1_11; -.
DR OrthoDB; 9801783at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0050570; F:4-hydroxythreonine-4-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR005255; PdxA_fam.
DR NCBIfam; TIGR00557; pdxA; 1.
DR PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR Pfam; PF04166; PdxA; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAM02734.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
SQ SEQUENCE 345 AA; 36423 MW; 80B1BB05DC311983 CRC64;
MSNGTARPIL AVTLGDPVGI GPEITARVLA EPEATETARP LAVGDATALR RAVEVCGLDV
EVNTVSEVSQ ARFEPGAIDI LDLGISPADL PWGQVDGTAG RSAVAAIETA TRAALEEDVD
AIVTSPINKE AIWAAGSEHL GHTEMLGELT GSDRFNTMFW VQGLKIFFAT RHMSLRRAVE
SITKDNIAHS IREAYTALEV FGTREPRLAV AALNPHGGEN GKFGDEEITA IAPAVEEARA
AGLNVFGPIP ADSVFHQGLQ GRYDGVLSLY HDQGHIASKT VDFDGTVSVT VGLPILRTSV
DHGTAFDIAG TGQADPGTMR SAFRAAVELA PFAGRLREVY PPKAR
//
