ID A4FHF5_SACEN Unreviewed; 594 AA.
AC A4FHF5;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Tetracycline resistance protein {ECO:0000313|EMBL:CAM03480.1, ECO:0000313|EMBL:PFG97175.1};
GN Name=tetM {ECO:0000313|EMBL:CAM03480.1};
GN OrderedLocusNames=SACE_4211 {ECO:0000313|EMBL:CAM03480.1};
GN ORFNames=A8924_4602 {ECO:0000313|EMBL:PFG97175.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03480.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03480.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM03480.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG97175.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG97175.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM03480.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG97175.1; -; Genomic_DNA.
DR RefSeq; WP_009949137.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FHF5; -.
DR STRING; 405948.SACE_4211; -.
DR KEGG; sen:SACE_4211; -.
DR eggNOG; COG0480; Bacteria.
DR HOGENOM; CLU_002794_4_1_11; -.
DR OrthoDB; 9801472at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 1..251
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 531..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 63263 MW; 40410FABBB5B3E53 CRC64;
MRTLNLGILA HVDAGKTSLT ERLLHSAGVV DEVGNVDDGS TRTDSTALER QRGITIRSAV
VSFVVGDVAV NLIDTPGHPD FIAEVERALG VLDGAVLVIS AVEGVQAQTR LLMRTLRRLR
IPTLVFVNKI DREGARHEDL LRDITAKVAR GSIPMGTPID LGTPAARYAS FGPSNRNFAA
ALLELLAEHD DALLAAYVDG KPEVSHSRLR RELAAQTSRM LVHPVFFGSA ITGAGVEDLM
SGLAELLPAS RGNADGPVSG TVFKAEREPG GNKVAHVRMF SGTVRVREAV RIRGQEHKVT
AIHVFDRGSA VRRRTVTAGR LARLCGLGDV RIGDAIGVPR ATAGEHHFSP PTLESVVLAR
RPSDGPALHT ALGLLAEQDP LIGLRHDGPR GELSVSLYGE VQKQVIQATL ADEHGIDVTF
RETTTICVGR PAGTGSAVEV IGEDTNPFLA TVGLRVDPAE AGTGVEFGLA VELGSLPLAF
VKAEEETVRE TLSQGLCGWQ VTDCVVTMTR SGYWARQSHS GGVFDKNMSS TAGDFRNLTP
RGRRAEPRAV PSPRCAACAG RPGRDRPPAA GRPAPGSPSR RCRAEPRHRG ARLR
//
