ID A4FKN9_SACEN Unreviewed; 297 AA.
AC A4FKN9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CAM04614.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CAM04614.1};
GN Name=glxR {ECO:0000313|EMBL:CAM04614.1};
GN OrderedLocusNames=SACE_5376 {ECO:0000313|EMBL:CAM04614.1};
GN ORFNames=A8924_5758 {ECO:0000313|EMBL:PFG98252.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04614.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM04614.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM04614.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG98252.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG98252.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; AM420293; CAM04614.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG98252.1; -; Genomic_DNA.
DR RefSeq; WP_009949482.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FKN9; -.
DR STRING; 405948.SACE_5376; -.
DR KEGG; sen:SACE_5376; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_11; -.
DR OMA; TGPAKFM; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CAM04614.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 5..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 169..287
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 175
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 297 AA; 29788 MW; D9F1141433C0FD0A CRC64;
MSTPVGVIGL GPMGANLALR LAEAGLDVVA TSRSQGTREA AAREGVRVVD DVRALAGRLR
AASPKPVVVV SLPSGPQVRA AVVDGLLADG GEFVVVDTST CAPADARSLA DDLHARGCAV
VDAPVSGGPT AARAGSLSVM VGGTEADVAA ADEVIRAFAG RVVVCGGPGA GQIAKACNQL
VVTAGIAVVA EALVTASALG ADPAAVREAL LGGYAASRIL ELHGDRMLRR DFTLGAAART
QLKDIGIIRE LTEGVVDNQV FEAAARAMEE LVESGGGDLD HSAAVRIVER RAGHSLG
//