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Database: UniProt
Entry: A4FKZ0_SACEN
LinkDB: A4FKZ0_SACEN
Original site: A4FKZ0_SACEN 
ID   A4FKZ0_SACEN            Unreviewed;      5856 AA.
AC   A4FKZ0;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=HTH cro/C1-type domain-containing protein {ECO:0000259|PROSITE:PS50943};
GN   OrderedLocusNames=SACE_5523 {ECO:0000313|EMBL:CAM04715.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04715.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM04715.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- SIMILARITY: Belongs to the enterotoxin A family.
CC       {ECO:0000256|ARBA:ARBA00009092}.
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DR   EMBL; AM420293; CAM04715.1; -; Genomic_DNA.
DR   STRING; 405948.SACE_5523; -.
DR   KEGG; sen:SACE_5523; -.
DR   eggNOG; COG1396; Bacteria.
DR   HOGENOM; CLU_223064_0_0_11; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 6.
DR   Gene3D; 3.90.210.10; Heat-Labile Enterotoxin, subunit A; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 6.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR001144; Enterotoxin_A.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   PANTHER; PTHR46797; HTH-TYPE TRANSCRIPTIONAL REGULATOR; 1.
DR   PANTHER; PTHR46797:SF1; METHYLPHOSPHONATE SYNTHASE; 1.
DR   Pfam; PF01375; Enterotoxin_a; 1.
DR   Pfam; PF13560; HTH_31; 6.
DR   SMART; SM00530; HTH_XRE; 6.
DR   SUPFAM; SSF56399; ADP-ribosylation; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 5.
DR   PROSITE; PS50943; HTH_CROC1; 6.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   TRANSMEM        124..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1116..1176
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   DOMAIN          1206..1263
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   DOMAIN          1286..1340
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   DOMAIN          1602..1656
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   DOMAIN          1682..1739
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   DOMAIN          1769..1823
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   REGION          360..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          793..897
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2007..2028
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2063..2137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2751..2770
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3632..3703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4363..4397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4659..4678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4688..4708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          5507..5528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..542
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        862..876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2107..2121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   5856 AA;  631391 MW;  657666EFF51C280E CRC64;
     MVVVVVSIRF TEEQRKLLLV VLGDDPTDAD EGWLFWVGEQ LEVKAVDVAE VGVVLRELVG
     RVLSEFSGKA ADRFEEQWVG FELFLERGGA VLSGVGEKVR EWALQVQYLK LMTLYGLNLL
     LAEMAWAVAM AALSFGAGVG AWLAFRFAVM RFLLRSWWGQ LFVRLAMAEV AGVGVQLVLD
     PAVQGTQIAM GTRKPDEWDE KATVDAVGVG AVSGLFALPM AALGNVVGNA VSGVLVRGLG
     GAVDEEVLVA AARHAVAEHA EKYPISAMAR FADAVGQSVK DYGGMSLGGM WAARVGSGLG
     EAIGEGLTEM FGEWAYTGEF NVFSGTAGSF DRVGEWVGEM GGLGLAGSLL PGGGSPYVAS
     GAGSGSDSDL APLVGKPSDL DDDAGDDSGY DSGYGSGGDS DAESVWSDEG SGSGSGVEVS
     GPLGGGAGWS TGPGLGAGAG AGVGESVSAG GGVSGPGGSS TAGAVAGASA GGLAGGSETS
     GGPSKGAAPA VGGGVSAAAQ PGPGTGPVES SGGPGVSPVG GVTGAVPVSQ GSVSQGSVSS
     GTGPAAGGAA GGEHGHGPGV SGSGAVAGVG AVPAASVDGG PVVSSAGSRT GGVVDPATNA
     GEVWAGDVEG VRSQTPPPPY TEFDTGAFSA PDVSVPPPAY SETEPGTVHS GQDGSGVDSA
     VGAGDGSGAQ TSVPGAVPVG GATAVGSGAA PSLAGLPSGG TEGARVVRVP EPTTGAGTEG
     VSAEQVRAQL GTGVPSAGGP VVVASQAASG GGVVMSPEQA KTLARELNND VVVLTPGRRG
     PRWMRFPANA ADGLAVRPSK PDTSPTATRT DLGSLTHAST AAPETAKTPT PTPTGPETVT
     ATADGSTGHT TTTMAAGKPG DLARPADRES TADRRGAGAS RKPVTARGHG RSVTLDEGRF
     PKDESALTVF AAGSARGRWI EGRLLSGEAL DAALAARRGG DRRPLRLVAC DSAVGGWESD
     AGRAAVRSGL PVLGVRGWVW QAKRGGRYPE GMASAAMVDG SGRPVLPPNG GYVLFVPGKP
     EPYDLGSYVP VSLGEVVAAV AAGDMARLDE LIANAEATAI TAAAVGRMST TGDAHAAEVY
     NGADTDWAHW ADTDTSHTAT GEQTLAQQRV VLGAALKRLR KAKKLAQRDI ATWLKEGGED
     RGAQSTVSLI ESGRYPPNRR ELLIMLNAYG VSREERARLQ ALHDAVDSTR SAPESDRKRA
     ELGNKLKEFR EAARLTKAGA ARAASLRVKQ GGNAISRIEN GGIPEKEQLR ALLEVYRVPE
     EEREELEALR DAVDPTRLSG VLGARLKLLR ERAKLSQCGA AAVSGVSRTR ISAGETGRAV
     PSVEQLGALL NVYDVSSEVR AEVEALWREA VASGGDGAAV PGAGEGHAGD GGPEAELLRE
     LDSLLRWLHA APEVLPGLRV QLDEFRADVA ELVVRGWPVP YVEAQLGVVR GLAERVRSSA
     FGFSEEEVRR LGWEVLLGHV EVARESLLQW DEGSVARWFA AADEFLGPWR AYEPLRVLMA
     HHFMLSPGDQ AGAEALREQF RPYVPGGVRG GAGPEPDGDG VSRSPVQAAE GMASDGLEGP
     ADAVREENRQ AMLARLERLA APTDDGIELG SATERISLGA RLKTLRDAAG LSQRDAATLS
     GVDHREISHY ELGERVPSEQ RLGALLDAYD VPVAERTEIE ALRDATVPIP GGQSPSQLGS
     KLTMLREAAG LSQRAAATQM RIDGINQASI SAFESGRAVP SVERLGALLN VYRVSIEESA
     EVEALRDAAV SVPGEQELAQ RRGVLGARLK LLRERAKLSQ RGAAAVSGVS RTRISDFETG
     RDVPSVEKLG ALLNVYDVSS EVRAEVEALC REAVASGGDG AAVPGAGEGH AGDGGPEAEL
     LRELDSLLRW LHAAPEVLPG LRVQLDEFRA DVAELVVRGW PVPYVEAQLG VVRGLAERVR
     SSAFGFSEEE VRRLGWEVLL GHVEVARESL LQWDEGSVAR WFAAADEFLG PWRAYEPLRV
     LMAHHFMLSP GDQAGAEALR EQFRPYVPGG VRGGAGPEPD GDGVSRSPVQ AAEGMASDGL
     EGPADAVREE NRQAMLARLE QLAGTGEDGA GPRSAVDTGD NRQGVDEYAG SVTASEPGSE
     SDSSSVAGVE HIEEYEHTDQ DDSSSAPSGT SARDDAERAA YEAAGPLVTA AFGGREESAA
     AVFQEHREAI GRWLVKHAGT PRAVHEFTAM WNELERPEPE SAERRAAPDE AVAAFRHLSV
     WARELHGSVN LGAAIAAGAE QVRDAARATL NLPGSELVGE AGARAARVAA AMEEMVAYRS
     YEDGMTPGAA QAPEFASKLR DTYRRLLSED AFQQESEVER FLSFYAAPLQ RATTWLESLG
     TAGREMAKRR DQARELFGAD FADLARSDAE RNLLDDLVDL VAHRNVGAEW ETPPDELRAL
     ARDMREDFEE LRWVVDVPAP VALDRVLHAR WHETVEVART TLGTLTEGQR TIAYRLASAF
     LGEPQPSRLS ADAHAAHAAW LYDWAVRYRG TDEAAKRFSG WNGHVLAEMR VTLDWPSVVS
     DPSVQYYRSR SPVWAAARQE ALRAVRRSMR RGAEWLREQA RTLLAFPSSG PRLSGELARR
     RIGLQRRVTE ILAWNLEVLR DPALVQPKAV RIRAELDRID EVAQDGSAAR GVHAMIDAYE
     ASTEDAFVSA SLGLALVDVD FGQYRDDGGR LLLASRFGLP GAPYGPAERA LLDDLVNLLA
     VRMASGMPES AARDLAESLA RDSHMPRTRT NPPDYIAREI VERLADEAGL ESAADGSASA
     PGADAEPPAA PSWLTEINAF REQYARFFDE LWADAGARSL SEVEYATKLG HSVFGDLSGL
     EAAAAEVAED LVLAHGELMR RHGDGFEESG PERADAFRAD WGSEFHTGLR AVAGKVLGQL
     LPEEPAPESV VRAFSRVPRW RESIDEAYAE LHSLVPRWLD KAREELGLPL PEPELSGGLE
     YEASKLRDEL AALVAFEASG SPRNLLRLWQ PGDDIKKFAE GLRQEYQEVL TRATNDPDGA
     LVLEYFRDDC RARVDEAKEG LDKLFRSVRD RWIARGREQL GGETFLPELS EARSQLLDDL
     AVTVGHRMQD RSNQALASAV NLLAENDSEV LETWRGQGHA DLGAVLAQSA LERDASDWVA
     RLAGYAPHLR ADIRSALHAL ATVEADTAQY WREEGARELV VSDDEHVPDV VASIAGYWLL
     AHPWPQAADL ATQAREAFNV LRDRFDPPLE VVEALLSDDA DDSDGSLDYD SASDGWFTPD
     TRDIDEIDAY VDARAPMAEG VWKGADGRDR PGDPQTWRDW IEHGEELYAW LEKARRMGWW
     RGRLLARIAA LKAEYRLGMT GELAEPHESE PRFELAAEPP YTPEHVANLR DSFGTYALEV
     LLPLADMLGD GLGDLGAASG VRRMARSLER DVRRFVTAVH DLSARAERDG SVPAQEFESL
     VRWAGRIQSF VSRNLDGFGF LHSDRDAANA LPRVIHSDIR FNVLLAASDI PGRLVSTVRP
     RYAFDAAVVE VDPNALRRLQ DSIQAEGLLW RVDRELLFRK DSRTPAEIKE ARGFAPRSSD
     LAVSLWGYQQ VPGESGLVSV SRSESLAAEF RMGGVHYESE YVYEIDALGG IDLVATLGRW
     TLLPYQQEVV FPGGILWEFV RGWRMVRDGK LGEFTPNPDY DPRGASPSES VSSPEPSGAP
     MVVRADGDQG FVVGVPGVSY PGPNRPDVLS DRSPQEGPLP PVVNRGDFEI EIVDGTPHVR
     LYTVVSMPQL PDGDVASGKP PAADVGDVQQ DPSTGKILIL NARLGRPLSV FVGRPLSALQ
     VLAAAEAELA ESQPWRSAVP PVIRSYLVPV DVVRELSGGA VAPEAYPNQA NGRVANVWPE
     FGPNLFAVPQ SLVGELAASV APNSLVTYTS GLGKEELLRG EWAGAVEHID GLRERLGVPR
     TELLPEWRPW PTMDELDRGS TWRVRRVGRG LRRHYATWQE VVSQPGGAPS TLPPDESVPF
     EERKVALEEF VARHLGAGML GRCVDHGRGG SCVVDEFMES TVRPWADQAA IAEVLAEDHG
     RMLKDLNITG KGAENDFAAL REQRPEREAH QRRVGARITE MWRDEGASPH EIIDYLVAKF
     PELSHKYDEI TVWNERYTYY EHAQMVLGQY LKLARAEAAE DRLVPVDTVV KAILFHDIEK
     DNAKRQQRSR FEQYRDEFAD FGRRGEEAAA EYGDEMARIA REAGAGRHDA AAEHVLAVDM
     VRRYGGIFAD DRQLAIAVDL IDSDPFGFYL MGRHSADDVF EYIARMALRV SGDSGASFGS
     VPELAESSTR DIQRLFNEFH QYYQADFSSY TSDSTYRKRE GSEPLNGLPT FDRYLGFRDG
     KLTRTADERH FEYSGRYREK FAELAAMFAS PEAVRASYER IAPPASDAQS PSGAQRASDG
     ELEAGPESAS TAVGEGVRGR HRRRFSRWLR NCFGADSDSE GQRLEGAAVP TAEVASPSVN
     EADVRVVRDA DGEVALVGFL SREGDEAAVA NLARRMPAGG HRTYRAKTRV GPVAVTRRRR
     VPWPRQRPPL YLYVHGDGVS GRVGGGAVGA AAFARMAWSM KVFQEAAVQQ RPIVLLSCDA
     RSNPVRDAGF ASELAKEFDK RGHAGGLWSV FGSPMVVDTR GRLDLREGKF VYHGERPAST
     SGGLRSWLTE FDRGRRSTPA ARAIFDGHGR RLSLGESDAV SDMEMASSAS RAAPQSGTVD
     DIEMVASPQQ GQRGTEAGPS HGSRQARSIE SLSVPEAQRM GLVPHALDYP KRISRAKPKP
     DPLAENLGVW ERIGELRSEL GQADGADVDR IRAEIDEQRA RLSGMLDAFL AAADAGQLAD
     AIGARLQLID HLRARRRELV EQGTVLSAPG WEVEHLDEQL VHVADEREVL VSEVAKRRLV
     DRPYQWMVPG ARDLEVVRWL KAFGETGERP DAELVGASEE QRVVFDGLAG RPGVSWRELS
     EAQVAALVVV ERKGRAQQRR DEERLLARLH RGGEGMEWAK AYPLNDRAEA RVLLEDVRRH
     MNENMLLATN YNFITPRGVL PFMQARPIPD DAPIPLDKIC DDPRQEFRSL WEIIKSERDF
     FLLRRGAHEE RLGYAATLQW DRAERMFRPD RDQRAQLPKY AALVSAYQTD GSAGDRYGAF
     VMYWEPEVAN RATYTPADSI AASGAAGING VTGANNKLGL LAEASPDVVR LAFAQATDFR
     HESEEFAEWV RNEGYNPDYI PGTYHGEYIE AQIHGSLRWT DLAAVVINYR DSLEDGAPTL
     QEAERVRTRL LAHARKHAYG FTVVLHKIGD PPPGPELFDQ IKARADVRQA ADRGEPISAV
     ELAAKYGKDL SWAFEQIFAV VRADVRQAAR QRRPRAVDSL VERFAISPED AEEQIAIDAR
     EDLRRVADKC PEDHYIDAAV NAPKFGKDPQ WLEDRIADAA RADVREAADA GRPYTKEDLA
     KRWKRSHKWA NDQIKAALAA AIREAADQGT LLTSDDWGGS YQEWVTRYNV HITLVRDSTS
     AAVRADVREA AEHGSPHRRA ELIRKYGPRH HWHLAGYRYA LPNHDRVPVG SPPNRQESDA
     RAEVRASVDR GEPYPVEALA KRYGKSRRWA FEQIAAAAHA DVLDAADRGE PYSVEALAER
     YGMSRRWAAS RLRGAHALVR GRYARAWEDA SSTAASGSPR TAVELAELHG ITVEQAQEQI
     DNAATGDAYR AAKRGAPYTA ATLSRRYGMK GASGVLWAQR RIEVAAYEYA RLLESTGAVS
     AFWLQHHFNL PESQAQQVLA RAARANVREA ADRGEPYTDD EVLDMYSTPD GTPTELAWVR
     TQVSLAAQAD VREAAARGRP YTAEELAKKY GRDEVWAQAQ IEAAAREAMR EAIASGEPCD
     AVEFFERFGV PVRWAKEQIE YLRNMPEHSD ADTEVG
//
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