ID A4FKZ0_SACEN Unreviewed; 5856 AA.
AC A4FKZ0;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=HTH cro/C1-type domain-containing protein {ECO:0000259|PROSITE:PS50943};
GN OrderedLocusNames=SACE_5523 {ECO:0000313|EMBL:CAM04715.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04715.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM04715.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SIMILARITY: Belongs to the enterotoxin A family.
CC {ECO:0000256|ARBA:ARBA00009092}.
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DR EMBL; AM420293; CAM04715.1; -; Genomic_DNA.
DR STRING; 405948.SACE_5523; -.
DR KEGG; sen:SACE_5523; -.
DR eggNOG; COG1396; Bacteria.
DR HOGENOM; CLU_223064_0_0_11; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 6.
DR Gene3D; 3.90.210.10; Heat-Labile Enterotoxin, subunit A; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 6.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR001144; Enterotoxin_A.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR46797; HTH-TYPE TRANSCRIPTIONAL REGULATOR; 1.
DR PANTHER; PTHR46797:SF1; METHYLPHOSPHONATE SYNTHASE; 1.
DR Pfam; PF01375; Enterotoxin_a; 1.
DR Pfam; PF13560; HTH_31; 6.
DR SMART; SM00530; HTH_XRE; 6.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 5.
DR PROSITE; PS50943; HTH_CROC1; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT TRANSMEM 124..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1116..1176
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 1206..1263
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 1286..1340
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 1602..1656
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 1682..1739
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 1769..1823
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT REGION 360..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2007..2028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2751..2770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3632..3703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4363..4397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4659..4678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4688..4708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5507..5528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5856 AA; 631391 MW; 657666EFF51C280E CRC64;
MVVVVVSIRF TEEQRKLLLV VLGDDPTDAD EGWLFWVGEQ LEVKAVDVAE VGVVLRELVG
RVLSEFSGKA ADRFEEQWVG FELFLERGGA VLSGVGEKVR EWALQVQYLK LMTLYGLNLL
LAEMAWAVAM AALSFGAGVG AWLAFRFAVM RFLLRSWWGQ LFVRLAMAEV AGVGVQLVLD
PAVQGTQIAM GTRKPDEWDE KATVDAVGVG AVSGLFALPM AALGNVVGNA VSGVLVRGLG
GAVDEEVLVA AARHAVAEHA EKYPISAMAR FADAVGQSVK DYGGMSLGGM WAARVGSGLG
EAIGEGLTEM FGEWAYTGEF NVFSGTAGSF DRVGEWVGEM GGLGLAGSLL PGGGSPYVAS
GAGSGSDSDL APLVGKPSDL DDDAGDDSGY DSGYGSGGDS DAESVWSDEG SGSGSGVEVS
GPLGGGAGWS TGPGLGAGAG AGVGESVSAG GGVSGPGGSS TAGAVAGASA GGLAGGSETS
GGPSKGAAPA VGGGVSAAAQ PGPGTGPVES SGGPGVSPVG GVTGAVPVSQ GSVSQGSVSS
GTGPAAGGAA GGEHGHGPGV SGSGAVAGVG AVPAASVDGG PVVSSAGSRT GGVVDPATNA
GEVWAGDVEG VRSQTPPPPY TEFDTGAFSA PDVSVPPPAY SETEPGTVHS GQDGSGVDSA
VGAGDGSGAQ TSVPGAVPVG GATAVGSGAA PSLAGLPSGG TEGARVVRVP EPTTGAGTEG
VSAEQVRAQL GTGVPSAGGP VVVASQAASG GGVVMSPEQA KTLARELNND VVVLTPGRRG
PRWMRFPANA ADGLAVRPSK PDTSPTATRT DLGSLTHAST AAPETAKTPT PTPTGPETVT
ATADGSTGHT TTTMAAGKPG DLARPADRES TADRRGAGAS RKPVTARGHG RSVTLDEGRF
PKDESALTVF AAGSARGRWI EGRLLSGEAL DAALAARRGG DRRPLRLVAC DSAVGGWESD
AGRAAVRSGL PVLGVRGWVW QAKRGGRYPE GMASAAMVDG SGRPVLPPNG GYVLFVPGKP
EPYDLGSYVP VSLGEVVAAV AAGDMARLDE LIANAEATAI TAAAVGRMST TGDAHAAEVY
NGADTDWAHW ADTDTSHTAT GEQTLAQQRV VLGAALKRLR KAKKLAQRDI ATWLKEGGED
RGAQSTVSLI ESGRYPPNRR ELLIMLNAYG VSREERARLQ ALHDAVDSTR SAPESDRKRA
ELGNKLKEFR EAARLTKAGA ARAASLRVKQ GGNAISRIEN GGIPEKEQLR ALLEVYRVPE
EEREELEALR DAVDPTRLSG VLGARLKLLR ERAKLSQCGA AAVSGVSRTR ISAGETGRAV
PSVEQLGALL NVYDVSSEVR AEVEALWREA VASGGDGAAV PGAGEGHAGD GGPEAELLRE
LDSLLRWLHA APEVLPGLRV QLDEFRADVA ELVVRGWPVP YVEAQLGVVR GLAERVRSSA
FGFSEEEVRR LGWEVLLGHV EVARESLLQW DEGSVARWFA AADEFLGPWR AYEPLRVLMA
HHFMLSPGDQ AGAEALREQF RPYVPGGVRG GAGPEPDGDG VSRSPVQAAE GMASDGLEGP
ADAVREENRQ AMLARLERLA APTDDGIELG SATERISLGA RLKTLRDAAG LSQRDAATLS
GVDHREISHY ELGERVPSEQ RLGALLDAYD VPVAERTEIE ALRDATVPIP GGQSPSQLGS
KLTMLREAAG LSQRAAATQM RIDGINQASI SAFESGRAVP SVERLGALLN VYRVSIEESA
EVEALRDAAV SVPGEQELAQ RRGVLGARLK LLRERAKLSQ RGAAAVSGVS RTRISDFETG
RDVPSVEKLG ALLNVYDVSS EVRAEVEALC REAVASGGDG AAVPGAGEGH AGDGGPEAEL
LRELDSLLRW LHAAPEVLPG LRVQLDEFRA DVAELVVRGW PVPYVEAQLG VVRGLAERVR
SSAFGFSEEE VRRLGWEVLL GHVEVARESL LQWDEGSVAR WFAAADEFLG PWRAYEPLRV
LMAHHFMLSP GDQAGAEALR EQFRPYVPGG VRGGAGPEPD GDGVSRSPVQ AAEGMASDGL
EGPADAVREE NRQAMLARLE QLAGTGEDGA GPRSAVDTGD NRQGVDEYAG SVTASEPGSE
SDSSSVAGVE HIEEYEHTDQ DDSSSAPSGT SARDDAERAA YEAAGPLVTA AFGGREESAA
AVFQEHREAI GRWLVKHAGT PRAVHEFTAM WNELERPEPE SAERRAAPDE AVAAFRHLSV
WARELHGSVN LGAAIAAGAE QVRDAARATL NLPGSELVGE AGARAARVAA AMEEMVAYRS
YEDGMTPGAA QAPEFASKLR DTYRRLLSED AFQQESEVER FLSFYAAPLQ RATTWLESLG
TAGREMAKRR DQARELFGAD FADLARSDAE RNLLDDLVDL VAHRNVGAEW ETPPDELRAL
ARDMREDFEE LRWVVDVPAP VALDRVLHAR WHETVEVART TLGTLTEGQR TIAYRLASAF
LGEPQPSRLS ADAHAAHAAW LYDWAVRYRG TDEAAKRFSG WNGHVLAEMR VTLDWPSVVS
DPSVQYYRSR SPVWAAARQE ALRAVRRSMR RGAEWLREQA RTLLAFPSSG PRLSGELARR
RIGLQRRVTE ILAWNLEVLR DPALVQPKAV RIRAELDRID EVAQDGSAAR GVHAMIDAYE
ASTEDAFVSA SLGLALVDVD FGQYRDDGGR LLLASRFGLP GAPYGPAERA LLDDLVNLLA
VRMASGMPES AARDLAESLA RDSHMPRTRT NPPDYIAREI VERLADEAGL ESAADGSASA
PGADAEPPAA PSWLTEINAF REQYARFFDE LWADAGARSL SEVEYATKLG HSVFGDLSGL
EAAAAEVAED LVLAHGELMR RHGDGFEESG PERADAFRAD WGSEFHTGLR AVAGKVLGQL
LPEEPAPESV VRAFSRVPRW RESIDEAYAE LHSLVPRWLD KAREELGLPL PEPELSGGLE
YEASKLRDEL AALVAFEASG SPRNLLRLWQ PGDDIKKFAE GLRQEYQEVL TRATNDPDGA
LVLEYFRDDC RARVDEAKEG LDKLFRSVRD RWIARGREQL GGETFLPELS EARSQLLDDL
AVTVGHRMQD RSNQALASAV NLLAENDSEV LETWRGQGHA DLGAVLAQSA LERDASDWVA
RLAGYAPHLR ADIRSALHAL ATVEADTAQY WREEGARELV VSDDEHVPDV VASIAGYWLL
AHPWPQAADL ATQAREAFNV LRDRFDPPLE VVEALLSDDA DDSDGSLDYD SASDGWFTPD
TRDIDEIDAY VDARAPMAEG VWKGADGRDR PGDPQTWRDW IEHGEELYAW LEKARRMGWW
RGRLLARIAA LKAEYRLGMT GELAEPHESE PRFELAAEPP YTPEHVANLR DSFGTYALEV
LLPLADMLGD GLGDLGAASG VRRMARSLER DVRRFVTAVH DLSARAERDG SVPAQEFESL
VRWAGRIQSF VSRNLDGFGF LHSDRDAANA LPRVIHSDIR FNVLLAASDI PGRLVSTVRP
RYAFDAAVVE VDPNALRRLQ DSIQAEGLLW RVDRELLFRK DSRTPAEIKE ARGFAPRSSD
LAVSLWGYQQ VPGESGLVSV SRSESLAAEF RMGGVHYESE YVYEIDALGG IDLVATLGRW
TLLPYQQEVV FPGGILWEFV RGWRMVRDGK LGEFTPNPDY DPRGASPSES VSSPEPSGAP
MVVRADGDQG FVVGVPGVSY PGPNRPDVLS DRSPQEGPLP PVVNRGDFEI EIVDGTPHVR
LYTVVSMPQL PDGDVASGKP PAADVGDVQQ DPSTGKILIL NARLGRPLSV FVGRPLSALQ
VLAAAEAELA ESQPWRSAVP PVIRSYLVPV DVVRELSGGA VAPEAYPNQA NGRVANVWPE
FGPNLFAVPQ SLVGELAASV APNSLVTYTS GLGKEELLRG EWAGAVEHID GLRERLGVPR
TELLPEWRPW PTMDELDRGS TWRVRRVGRG LRRHYATWQE VVSQPGGAPS TLPPDESVPF
EERKVALEEF VARHLGAGML GRCVDHGRGG SCVVDEFMES TVRPWADQAA IAEVLAEDHG
RMLKDLNITG KGAENDFAAL REQRPEREAH QRRVGARITE MWRDEGASPH EIIDYLVAKF
PELSHKYDEI TVWNERYTYY EHAQMVLGQY LKLARAEAAE DRLVPVDTVV KAILFHDIEK
DNAKRQQRSR FEQYRDEFAD FGRRGEEAAA EYGDEMARIA REAGAGRHDA AAEHVLAVDM
VRRYGGIFAD DRQLAIAVDL IDSDPFGFYL MGRHSADDVF EYIARMALRV SGDSGASFGS
VPELAESSTR DIQRLFNEFH QYYQADFSSY TSDSTYRKRE GSEPLNGLPT FDRYLGFRDG
KLTRTADERH FEYSGRYREK FAELAAMFAS PEAVRASYER IAPPASDAQS PSGAQRASDG
ELEAGPESAS TAVGEGVRGR HRRRFSRWLR NCFGADSDSE GQRLEGAAVP TAEVASPSVN
EADVRVVRDA DGEVALVGFL SREGDEAAVA NLARRMPAGG HRTYRAKTRV GPVAVTRRRR
VPWPRQRPPL YLYVHGDGVS GRVGGGAVGA AAFARMAWSM KVFQEAAVQQ RPIVLLSCDA
RSNPVRDAGF ASELAKEFDK RGHAGGLWSV FGSPMVVDTR GRLDLREGKF VYHGERPAST
SGGLRSWLTE FDRGRRSTPA ARAIFDGHGR RLSLGESDAV SDMEMASSAS RAAPQSGTVD
DIEMVASPQQ GQRGTEAGPS HGSRQARSIE SLSVPEAQRM GLVPHALDYP KRISRAKPKP
DPLAENLGVW ERIGELRSEL GQADGADVDR IRAEIDEQRA RLSGMLDAFL AAADAGQLAD
AIGARLQLID HLRARRRELV EQGTVLSAPG WEVEHLDEQL VHVADEREVL VSEVAKRRLV
DRPYQWMVPG ARDLEVVRWL KAFGETGERP DAELVGASEE QRVVFDGLAG RPGVSWRELS
EAQVAALVVV ERKGRAQQRR DEERLLARLH RGGEGMEWAK AYPLNDRAEA RVLLEDVRRH
MNENMLLATN YNFITPRGVL PFMQARPIPD DAPIPLDKIC DDPRQEFRSL WEIIKSERDF
FLLRRGAHEE RLGYAATLQW DRAERMFRPD RDQRAQLPKY AALVSAYQTD GSAGDRYGAF
VMYWEPEVAN RATYTPADSI AASGAAGING VTGANNKLGL LAEASPDVVR LAFAQATDFR
HESEEFAEWV RNEGYNPDYI PGTYHGEYIE AQIHGSLRWT DLAAVVINYR DSLEDGAPTL
QEAERVRTRL LAHARKHAYG FTVVLHKIGD PPPGPELFDQ IKARADVRQA ADRGEPISAV
ELAAKYGKDL SWAFEQIFAV VRADVRQAAR QRRPRAVDSL VERFAISPED AEEQIAIDAR
EDLRRVADKC PEDHYIDAAV NAPKFGKDPQ WLEDRIADAA RADVREAADA GRPYTKEDLA
KRWKRSHKWA NDQIKAALAA AIREAADQGT LLTSDDWGGS YQEWVTRYNV HITLVRDSTS
AAVRADVREA AEHGSPHRRA ELIRKYGPRH HWHLAGYRYA LPNHDRVPVG SPPNRQESDA
RAEVRASVDR GEPYPVEALA KRYGKSRRWA FEQIAAAAHA DVLDAADRGE PYSVEALAER
YGMSRRWAAS RLRGAHALVR GRYARAWEDA SSTAASGSPR TAVELAELHG ITVEQAQEQI
DNAATGDAYR AAKRGAPYTA ATLSRRYGMK GASGVLWAQR RIEVAAYEYA RLLESTGAVS
AFWLQHHFNL PESQAQQVLA RAARANVREA ADRGEPYTDD EVLDMYSTPD GTPTELAWVR
TQVSLAAQAD VREAAARGRP YTAEELAKKY GRDEVWAQAQ IEAAAREAMR EAIASGEPCD
AVEFFERFGV PVRWAKEQIE YLRNMPEHSD ADTEVG
//