ID A4FL91_SACEN Unreviewed; 835 AA.
AC A4FL91;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=DEAD/DEAH box helicase-like {ECO:0000313|EMBL:CAM04816.1};
DE SubName: Full=Superfamily II RNA helicase {ECO:0000313|EMBL:PFG98456.1};
GN OrderedLocusNames=SACE_5630 {ECO:0000313|EMBL:CAM04816.1};
GN ORFNames=A8924_5970 {ECO:0000313|EMBL:PFG98456.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04816.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM04816.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM04816.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG98456.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG98456.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR EMBL; AM420293; CAM04816.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG98456.1; -; Genomic_DNA.
DR RefSeq; WP_009944591.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FL91; -.
DR STRING; 405948.SACE_5630; -.
DR KEGG; sen:SACE_5630; -.
DR eggNOG; COG4581; Bacteria.
DR HOGENOM; CLU_017075_0_0_11; -.
DR OrthoDB; 3229913at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17921; DEXHc_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR021904; DUF3516.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF12029; DUF3516; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CAM04816.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 39..182
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 235..419
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 835 AA; 92459 MW; 88EC7DF5A74CA118 CRC64;
MMLTDQLPAT PEPDALLDAF VTWTTHQGID LYPAQEEALM EVVTGANVIL STPTGSGKSL
VATGAHFVAL ASGRRTFYTA PIKALVSEKF FALVDVFGAA DVGMMTGDSS VNADAPIICC
TAEILANIAL RDGERADVGQ VVMDEFHFYS EPDRGWAWQV PLLELPQAQF VLMSATLGDV
TRFRDDLTRR TGRDTAVVSS AERPIPLTFR YAMTPLHETI EELLAGQQAP VYVVYFNQAS
ALEQAQALMS VNVASREQRD RIAEAIGDFR FTAGFGKTLS RLVRHGIGVH HAGMLPKYRR
LVEQLAQAGL LKVICGTDTL GVGINVPIRT VLLTGLTKYD GVRTRHLKAR EFHQIAGRAG
RAGYDTAGYV VVQAPEHVIE NERAVAKAGD DPKKKRKLVR KKAPEGFVSW SEKTFEKLVE
AEPEPLTSSF VVSHSMLLNV INRPGDAFAA MRHLLTENHE DRAAQRRHIL RAIAIYRALL
AAGVVEQLDE PDEQGRRARL TVDLQFDFAL NQPLSPFALA AIELLDVDSP SYPLDVLSVI
ESTLDDPRQV LSAQQFKARG EAVAQMKADG IEYDERMELL EDITHPKPLE ELLEAAYEMY
RKGHPWVGEH ELSPKSVARD MYERAMNFVE FVNHYGLARS EGLVLRYLAD VYKALRHTVP
DDAKTEELGD IIEWLGELVR QVDSSLLDEW ERLRNPAAED TSSAAPASAE EGPARITANK
RAFRVQVRNA LFRRVELAAR REHEQLGALD PELGADGWAD ALDDYFEQHD EIGTGPDARG
PALLMITEEQ SRWVVRQIFD DPAGDHDWGF SAEVDLAESD EAGEAVVRVT SVDQL
//
