ID A4FN23_SACEN Unreviewed; 305 AA.
AC A4FN23;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=DNA-binding transcriptional LysR family regulator {ECO:0000313|EMBL:PFG99089.1};
DE SubName: Full=LysR-family transcriptional regulator {ECO:0000313|EMBL:CAM05448.1};
GN OrderedLocusNames=SACE_6276 {ECO:0000313|EMBL:CAM05448.1};
GN ORFNames=A8924_6624 {ECO:0000313|EMBL:PFG99089.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM05448.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM05448.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM05448.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG99089.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG99089.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00009437}.
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DR EMBL; AM420293; CAM05448.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG99089.1; -; Genomic_DNA.
DR RefSeq; WP_009948484.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FN23; -.
DR STRING; 405948.SACE_6276; -.
DR KEGG; sen:SACE_6276; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_6_0_11; -.
DR OrthoDB; 3673085at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR CDD; cd08423; PBP2_LTTR_like_6; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30346:SF16; SMALL NEUTRAL PROTEASE REGULATORY PROTEIN; 1.
DR PANTHER; PTHR30346; TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED; 1.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000313|EMBL:PFG99089.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 3..60
FT /note="HTH lysR-type"
FT /evidence="ECO:0000259|PROSITE:PS50931"
SQ SEQUENCE 305 AA; 32546 MW; 447D1C57DE6A28CC CRC64;
MAVDPSRLLV LLAIREQGSV TRAAEQTGRT PPAVSQQLAR LEAEVGAQLV ERLPHGARLT
PLGTRLADHA ERIADAVRRA DAETADYLDR HRNRLRLGAF PTAGLALLPD VLAALRHRHP
DAELSVVDLG PVEGMALVGS HELDLALVGE YGTPLDAPPG VRLAPLIDDP VHAVLPTDHR
LADHPAVRLA DFADEPWAAA PRTLPNRRQL EEATRAQGFL PNVPFESESY AVAEAVVSAG
VAVAFIPRLA ISGTSGTVHR PLAEPGLFRR IHAVVPASAG HAPLTEVCLR LLENLCAELA
ERFGG
//
