ID A4FXQ5_METM5 Unreviewed; 317 AA.
AC A4FXQ5;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein {ECO:0000313|EMBL:ABO34989.1};
GN OrderedLocusNames=MmarC5_0678 {ECO:0000313|EMBL:ABO34989.1};
OS Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=402880 {ECO:0000313|EMBL:ABO34989.1, ECO:0000313|Proteomes:UP000000253};
RN [1] {ECO:0000313|EMBL:ABO34989.1, ECO:0000313|Proteomes:UP000000253}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC BAA-1333 {ECO:0000313|Proteomes:UP000000253};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP000609; ABO34989.1; -; Genomic_DNA.
DR RefSeq; WP_011868443.1; NC_009135.1.
DR AlphaFoldDB; A4FXQ5; -.
DR STRING; 402880.MmarC5_0678; -.
DR GeneID; 4927647; -.
DR KEGG; mmq:MmarC5_0678; -.
DR eggNOG; arCOG01755; Archaea.
DR HOGENOM; CLU_019796_1_3_2; -.
DR OrthoDB; 34275at2157; -.
DR Proteomes; UP000000253; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 20..316
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..285
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 317 AA; 35108 MW; 69092398BDA68A71 CRC64;
MKIVVLDGYT MNSGDLSWSN LEKFGELNVY DRTSESEVIE RISDSEIVIT NKVIIGREVF
EKCKNIKYVG VTATGYNVVD TNLAKEFGVT VTNVPAYSTD SVSQLVFSFI LEYCQNVYKY
NESVKSGDWV NSKDFSYRKF PIVELAGKNL GIIGFGAIGK KVAEIGNAFG MNVIVNTRTI
SNTNLNVKFV SKEEIFKNSD FLTLHCPLTD ETKEIINKNT LELMKTSSFL INTGRGGLVN
EKNLADALNL GNIAGAGLDV LSNEPPKEDN PLINAKNTFI TPHVAWASYE ARNRLMNVTI
NNVKSFIEGN PINVVNK
//
