ID A4G065_METM5 Unreviewed; 341 AA.
AC A4G065;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ABO35849.1};
GN OrderedLocusNames=MmarC5_1552 {ECO:0000313|EMBL:ABO35849.1};
OS Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=402880 {ECO:0000313|EMBL:ABO35849.1, ECO:0000313|Proteomes:UP000000253};
RN [1] {ECO:0000313|EMBL:ABO35849.1, ECO:0000313|Proteomes:UP000000253}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC BAA-1333 {ECO:0000313|Proteomes:UP000000253};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP000609; ABO35849.1; -; Genomic_DNA.
DR RefSeq; WP_011869296.1; NC_009135.1.
DR AlphaFoldDB; A4G065; -.
DR STRING; 402880.MmarC5_1552; -.
DR DNASU; 4929098; -.
DR GeneID; 4929098; -.
DR KEGG; mmq:MmarC5_1552; -.
DR eggNOG; arCOG00658; Archaea.
DR HOGENOM; CLU_033172_0_0_2; -.
DR OrthoDB; 61910at2157; -.
DR Proteomes; UP000000253; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004076; F:biotin synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009102; P:biotin biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR002684; Biotin_synth/BioAB.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023858; RSAM_HmdB.
DR NCBIfam; TIGR03957; rSAM_HmdB; 1.
DR PANTHER; PTHR22976; BIOTIN SYNTHASE; 1.
DR PANTHER; PTHR22976:SF2; BIOTIN SYNTHASE, MITOCHONDRIAL; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF004762; CHP00423; 1.
DR SFLD; SFLDF00330; HMD_cofactor_maturase_(HmdB-li; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 58..281
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 341 AA; 37298 MW; 08D37BABC68B5360 CRC64;
MIFSKIRGNF QDLKDGKISV KQGLITKSDA IELFNIKNWK DYLKLFSIAS EVRDFFKNEI
EITSTVHVTN ICSVTPKCAY CGFAAGTSSE GYVEPFRSND EQIKSSAAAV ENSGIKRVSC
SSGHGYSGKE VIRALKAVKS ASNLEVLVNA GADITEDCIS ELKKYNIDTI CCNLETTNKS
VFNKVKPGEN LDDRISVCKM VKKHGIELSS GLLIGIGESY EDRAEHLFFL KELDVEEIPV
MGFNPYKDTP MEQCPKCSAI EQAKTIAIAR LLFPNIRITS PTPTMGPELA QFALLGGASN
IATVIPDNHP MNIKGVGNPK TGNLNDVICM MKELGLTPKL N
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