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Database: UniProt
Entry: A4G646
LinkDB: A4G646
Original site: A4G646 
ID   TPIS_HERAR              Reviewed;         248 AA.
AC   A4G646;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-SEP-2014, entry version 50.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=HEAR1828;
OS   Herminiimonas arsenicoxydans.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herminiimonas.
OX   NCBI_TaxID=204773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ULPAs1;
RX   PubMed=17432936; DOI=10.1371/journal.pgen.0030053;
RA   Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E.,
RA   Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M.,
RA   Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M.,
RA   Leize E., Lieutaud A., Lievremont D., Makita Y., Mangenot S.,
RA   Nitschke W., Ortet P., Perdrial N., Schoepp B., Siguier P.,
RA   Simeonova D.D., Rouy Z., Segurens B., Turlin E., Vallenet D.,
RA   van Dorsselaer A., Weiss S., Weissenbach J., Lett M.-C., Danchin A.,
RA   Bertin P.N.;
RT   "A tale of two oxidation states: bacterial colonization of arsenic-
RT   rich environments.";
RL   PLoS Genet. 3:518-530(2007).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CU207211; CAL61983.1; -; Genomic_DNA.
DR   RefSeq; WP_011871310.1; NC_009138.1.
DR   RefSeq; YP_001100108.1; NC_009138.1.
DR   ProteinModelPortal; A4G646; -.
DR   STRING; 204773.HEAR1828; -.
DR   PRIDE; A4G646; -.
DR   EnsemblBacteria; CAL61983; CAL61983; HEAR1828.
DR   GeneID; 4931353; -.
DR   KEGG; har:HEAR1828; -.
DR   PATRIC; 22113722; VBIHerArs17568_1730.
DR   eggNOG; COG0149; -.
DR   HOGENOM; HOG000226413; -.
DR   KO; K01803; -.
DR   OMA; PAIYLDQ; -.
DR   OrthoDB; EOG66QM23; -.
DR   BioCyc; HARS204773:GJCA-1766-MONOMER; -.
DR   UniPathway; UPA00109; UER00189.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00147_B; TIM_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR022896; TrioseP_Isoase_bac/euk.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR   PANTHER; PTHR21139; PTHR21139; 1.
DR   Pfam; PF00121; TIM; 1.
DR   SUPFAM; SSF51351; SSF51351; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    248       Triosephosphate isomerase.
FT                                /FTId=PRO_0000307481.
FT   ACT_SITE     94     94       Electrophile (By similarity).
FT   ACT_SITE    166    166       Proton acceptor (By similarity).
FT   BINDING       9      9       Substrate (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
SQ   SEQUENCE   248 AA;  26283 MW;  8F241F52CE1379AF CRC64;
     MRRKLVAGNW KMNGSLAANA LLLAEIKAEF GNPACDVAVC VPAPYLAQCL SLLSDSTIAL
     GAQDVSSHDS GAYTGEVSTA MLLEFACRYV IVGHSERRAY FGETNELVAQ KTVRALSAGL
     MPIVCVGETL EQREAGQTDE VVGRQIDAVL SSIAENDLAK IVVAYEPVWA IGTGKTATPE
     MAQEVHVMLR RRLHAKNAQA ATEVRILYGG SMKPDNAKEL LAMPDIDGGL IGGAALKAAD
     FLAIIRAA
//
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