ID A4GWJ8_LISMN Unreviewed; 800 AA.
AC A4GWJ8; V9XUM9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=InlA {ECO:0000313|EMBL:ABO32393.1, ECO:0000313|EMBL:EAC5551162.1};
DE SubName: Full=Internalin {ECO:0000313|EMBL:ACM69350.1, ECO:0000313|EMBL:HAA8053455.1};
DE Flags: Fragment;
GN Name=inlA {ECO:0000313|EMBL:ABO32393.1};
GN ORFNames=ARY78_12050 {ECO:0000313|EMBL:EAC5551162.1}, CW845_11315
GN {ECO:0000313|EMBL:EAG9388073.1}, E5F58_04255
GN {ECO:0000313|EMBL:EAH4241213.1}, FV747_14330
GN {ECO:0000313|EMBL:EDO0987176.1}, GHH22_09840
GN {ECO:0000313|EMBL:HAA8053455.1};
OS Listeria monocytogenes.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=1639 {ECO:0000313|EMBL:ABO32393.1};
RN [1] {ECO:0000313|EMBL:ABO32393.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17660431; DOI=10.1099/mic.0.2007/007310-0;
RA Orsi R.H., Ripoll D.R., Yeung M., Nightingale K.K., Wiedmann M.;
RT "Recombination and positive selection contribute to evolution of Listeria
RT monocytogenes inlA.";
RL Microbiology 153:2666-2678(2007).
RN [2] {ECO:0000313|EMBL:CAQ76830.1}
RP NUCLEOTIDE SEQUENCE.
RA Ragon M., Wirth T., Hollandt F., Lavenir R., Lecuit M., Le Monnier A.,
RA Brisse S.;
RT "A new perspective on Listeria monocytogenes evolution.";
RL PLoS Pathog. 4:e1000146-e1000146(2008).
RN [3] {ECO:0000313|EMBL:ACM69350.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CSUFSL N1-008 {ECO:0000313|EMBL:ACM69350.1};
RX PubMed=19581477; DOI=10.1128/AEM.00367-09;
RA Roberts A.J., Williams S.K., Wiedmann M., Nightingale K.K.;
RT "Some Listeria monocytogenes outbreak strains demonstrate significantly
RT reduced invasion, inlA transcript levels, and swarming motility in vitro.";
RL Appl. Environ. Microbiol. 75:5647-5658(2009).
RN [4] {ECO:0000313|EMBL:ADE73848.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=4446 {ECO:0000313|EMBL:ADE73848.1};
RX PubMed=20348313; DOI=10.1128/AEM.02862-09;
RA Holch A., Gottlieb C.T., Larsen M.H., Ingmer H., Gram L.;
RT "Poor invasion of trophoblastic cells but normal plaque formation in
RT fibroblastic cells despite actA deletion in a group of Listeria
RT monocytogenes strains persisting in some food processing environments.";
RL Appl. Environ. Microbiol. 76:3391-3397(2010).
RN [5] {ECO:0000313|EMBL:ADI77521.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL_B-33322 {ECO:0000313|EMBL:ADI77521.1};
RX PubMed=20501037;
RA Ward T.J., Evans P., Wiedmann M., Usgaard T., Roof S.E., Stroika S.G.,
RA Hise K.;
RT "Molecular and phenotypic characterization of Listeria monocytogenes from
RT U.S. Department of Agriculture Food Safety and Inspection Service
RT surveillance of ready-to-eat foods and processing facilities.";
RL J. Food Prot. 73:861-869(2010).
RN [6] {ECO:0000313|EMBL:ACA05634.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 19115 {ECO:0000313|EMBL:ACA05634.1};
RX PubMed=23267677; DOI=10.1186/1471-2180-12-304;
RA Roche S.M., Grepinet O., Kerouanton A., Ragon M., Leclercq A., Temoin S.,
RA Schaeffer B., Skorski G., Mereghetti L., Le Monnier A., Velge P.;
RT "Polyphasic characterization and genetic relatedness of low-virulence and
RT virulent Listeria monocytogenes isolates.";
RL BMC Microbiol. 12:304-304(2012).
RN [7] {ECO:0000313|EMBL:AGC92219.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FF_46-3 {ECO:0000313|EMBL:AGC92219.1};
RX PubMed=23315746; DOI=10.1128/AEM.03341-12;
RA Kovacevic J., Arguedas-Villa C., Wozniak A., Tasara T., Allen K.J.;
RT "Examination of Food Chain-Derived Listeria monocytogenes Strains of
RT Different Serotypes Reveals Considerable Diversity in inlA Genotypes,
RT Mutability, and Adaptation to Cold Temperatures.";
RL Appl. Environ. Microbiol. 79:1915-1922(2013).
RN [8] {ECO:0000313|EMBL:AHD46157.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RM15663 {ECO:0000313|EMBL:AHD46157.2}, and RM15695
RC {ECO:0000313|EMBL:AHD46172.1};
RX PubMed=24651315;
RA Gorski L., Walker S., Liang A.S., Nguyen K.M., Govoni J., Carychao D.,
RA Cooley M.B., Mandrell R.E.;
RT "Comparison of subtypes of Listeria monocytogenes isolates from naturally
RT contaminated watershed samples with and without a selective secondary
RT enrichment.";
RL PLoS ONE 9:E92467-E92467(2014).
RN [9] {ECO:0000313|EMBL:BAR47510.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=To204f {ECO:0000313|EMBL:BAR47510.1};
RX PubMed=26143289;
RA Kanki M., Naruse H., Taguchi M., Kumeda Y.;
RT "Characterization of specific alleles in InlA and PrfA of Listeria
RT monocytogenes isolated from foods in Osaka, Japan and their ability to
RT invade Caco-2 cells.";
RL Int. J. Food Microbiol. 211:18-22(2015).
RN [10] {ECO:0000313|EMBL:AHD46157.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RM15663 {ECO:0000313|EMBL:AHD46157.2};
RA Gorski L.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=09CEB371LM;
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [12] {ECO:0000313|EMBL:HAA8053455.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09CEB371LM {ECO:0000313|EMBL:HAA8053455.1};
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:0-153(2018).
RN [13] {ECO:0000313|EMBL:EAC5551162.1, ECO:0000313|Proteomes:UP000365297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDA00007096 {ECO:0000313|EMBL:EAC5551162.1,
RC ECO:0000313|Proteomes:UP000365297}, and LS1344
RC {ECO:0000313|EMBL:EAH4241213.1, ECO:0000313|Proteomes:UP000527632};
RG GenomeTrakr: Next Generation Sequencing Network for Food Pathogen Tracability;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:EAG9388073.1, ECO:0000313|Proteomes:UP000522199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFSAN072474 {ECO:0000313|EMBL:EAG9388073.1,
RC ECO:0000313|Proteomes:UP000522199};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:EDO0987176.1, ECO:0000313|Proteomes:UP000467536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=788324 {ECO:0000313|EMBL:EDO0987176.1,
RC ECO:0000313|Proteomes:UP000467536};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:HAA8053455.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=09CEB371LM {ECO:0000313|EMBL:HAA8053455.1};
RG NCBI Pathogen Detection Project;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the internalin family.
CC {ECO:0000256|ARBA:ARBA00009432}.
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DR EMBL; EF445900; ABO32393.1; -; Genomic_DNA.
DR EMBL; EF445903; ABO32396.1; -; Genomic_DNA.
DR EMBL; EU295337; ACA05634.1; -; Genomic_DNA.
DR EMBL; FJ617524; ACM69350.1; -; Genomic_DNA.
DR EMBL; GU735669; ADE73848.1; -; Genomic_DNA.
DR EMBL; GQ414086; ADI77521.1; -; Genomic_DNA.
DR EMBL; KC433366; AGC92219.1; -; Genomic_DNA.
DR EMBL; KF728274; AHD46157.2; -; Genomic_DNA.
DR EMBL; KF728289; AHD46172.1; -; Genomic_DNA.
DR EMBL; LC005874; BAR47510.1; -; Genomic_DNA.
DR EMBL; FM178780; CAQ76830.1; -; Genomic_DNA.
DR EMBL; AAAIXK010000006; EAC5551162.1; -; Genomic_DNA.
DR EMBL; AABEKY010000006; EAG9388073.1; -; Genomic_DNA.
DR EMBL; AABGUK010000001; EAH4241213.1; -; Genomic_DNA.
DR EMBL; AANEHK010000020; EDO0987176.1; -; Genomic_DNA.
DR EMBL; DAAEEB010000006; HAA8053455.1; -; Genomic_DNA.
DR RefSeq; WP_003734628.1; NZ_VTKJ01000005.1.
DR KEGG; lmok:CQ02_02440; -.
DR PATRIC; fig|1639.1036.peg.1406; -.
DR Proteomes; UP000365297; Unassembled WGS sequence.
DR Proteomes; UP000467536; Unassembled WGS sequence.
DR Proteomes; UP000522199; Unassembled WGS sequence.
DR Proteomes; UP000527632; Unassembled WGS sequence.
DR Proteomes; UP000840039; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR012569; Inl_IR.
DR InterPro; IPR047600; InlA.
DR InterPro; IPR013378; InlB-like_B-rpt.
DR InterPro; IPR024634; Internalin_N.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR032675; LRR_dom_sf.
DR NCBIfam; NF033189; internalin_A; 1.
DR NCBIfam; TIGR02543; List_Bact_rpt; 3.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF09479; Flg_new; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF12354; Internalin_N; 1.
DR Pfam; PF12799; LRR_4; 6.
DR Pfam; PF08191; LRR_adjacent; 1.
DR SMART; SM00365; LRR_SD22; 14.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51450; LRR; 13.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 776..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 767..800
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 705..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 800
FT /evidence="ECO:0000313|EMBL:ABO32393.1"
SQ SEQUENCE 800 AA; 86631 MW; DE837CC0045993E7 CRC64;
MRRKRYVWLK SILVAILVFG SGVWINTSNG TNAQAATITQ DTPINQIFTD TALAEKMKTV
LGKTNVTDTV SQTDLDQVTT LQADRLGIKS IDGLEYLNNL TQINFSNNQL TDITPLKDLT
KLVDILMNNN QIADITPLAN LSNLTGLTLF NNQITDIDPL KNLTNLNRLE LSSNTISDIS
ALSGLTSLQQ LSFGNQVTDL KPLANLTTLE RLDISSNKVS DISVLAKLTN LESLIATNNQ
ISDITPLGIL TNLDELSLNG NQLKDIGTLA SLTNLTDLDL ANNQISNLAP LSGLTKLTEL
KLGANQISNI SPLAGLTALT NLELNENQLE DISPISNLKN LTYLTLYFNN ISDISPVSSL
TKLQRLFFYN NKVSDVSSLA NLTNINWLSA GHNQISDLTP LANLTRITQL GLNDQEWTNP
PVNYKVNVSI PNTVKNVTGA LIAPATISDG GSYAEPDITW NLPSYTNEVS YTFNQSVTIG
KGTTTFSGTV TQPLKAIFNA KFHVDGKETT KEVEAGNLLT EPAKPVKEGY TFVGWFDAQT
GGTKWNFSTD KMPTNDIDLY AQFSINSYTA TFDNDGVTTS QTVDYQGLLQ EPTAPTKEGY
TFKGWYDAKT GGDKWDFATS KMPAKNITLY AQYSANSYTA TFDVDGKTTT QAVDYQGLLK
EPKTPTKAGY TFKGWYDEKT DGKKWDFATD KMPANDITLY AQFTKNPVAP PTTGGNTPPT
TNNGGNTTPP SANIPGSNTS NTSTGNSAST TSTMNAYDPY NSKEASLPTT GDSDNALYLL
IGLLAVGTAV ALTKKARASK
//