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Database: UniProt
Entry: A4H4Y3_LEIBR
LinkDB: A4H4Y3_LEIBR
Original site: A4H4Y3_LEIBR 
ID   A4H4Y3_LEIBR            Unreviewed;       828 AA.
AC   A4H4Y3;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 2.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LBRM_07_0390 {ECO:0000313|EMBL:CAM41651.2};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41651.2,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41651.2,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006608}.
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DR   EMBL; FR798981; CAM41651.2; -; Genomic_DNA.
DR   RefSeq; XP_001562535.2; XM_001562485.2.
DR   AlphaFoldDB; A4H4Y3; -.
DR   STRING; 5660.A4H4Y3; -.
DR   GeneID; 5412957; -.
DR   KEGG; lbz:LBRM_07_0390; -.
DR   VEuPathDB; TriTrypDB:LbrM.07.0390; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_070010300; -.
DR   InParanoid; A4H4Y3; -.
DR   Proteomes; UP000007258; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131:SF94; MATH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 2.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00207}.
FT   DOMAIN          296..336
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          421..455
FT                   /note="TRAF-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50145"
FT   DOMAIN          709..823
FT                   /note="MATH"
FT                   /evidence="ECO:0000259|PROSITE:PS50144"
FT   ZN_FING         421..455
FT                   /note="TRAF-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          635..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  86359 MW;  3AC2AC9A0FCF1EB4 CRC64;
     MSSWTNAPAS SCAAAAPNHL PGTSTSPSAT CRRREAAVYP TSGAAPTFLG AVITFGASGC
     MATPLVAAPG THCDDHTPTC TAARVAPAPP SGAPSAAAAA GQHDCVSQDF SGPLQRPSPT
     VLHLYATTTT AAGTANPKRR HGLLPPPIMS DVTRALGHRS CSCPNTRSTP AADAAIASSP
     VSTNSGVVTR SRAAVAATNS SSTLQVTGNQ SSPNDMLTKE TVPFPIYSFK PLGLWSALPT
     TGVTATAAVS ASATTLELEA STATTNGVDV GTLLTHEMDS GVVIVDPCQT PDDLVCGVCM
     SVCRHPTATT CGHLFCRRCL QGWMQANPAA MCPLDRTPIQ VELLHTDARA QRQINALPCH
     CPASLSRASQ LELRQLGSAH RVLGDGTAEE GGDVGGTRGD ECARQAHPRC TWAGCVSDAA
     AHMCQCPHII IECPFAKHGC AVELPRSDMA SHLKNYVADH LLLLSQALDA SVEQCRALQG
     EVEVLRQRCP MRYPVALPNV PTGGPTGSSA PTISVSSSLL HGATTATSVP GMDVPTAVPT
     PALVISNGSS SGAATIAMAA LPEEVSMSSV SLLRVAGSFG HGASTAVDYP SPVFSQSLRP
     YYHLHHRSST AVEPTNLRRG TATEDMLLAA THRVPNGHDA TTPMAMDTTP VRTPSPSRLG
     ASPGSVPVAN LAAAAATFVL PPGAATLLPT PVASAPSRAA PVVGGICGVD RFVWVITDVA
     SLQAPCYSRP FSSHNVPWYV GMDTTATWEQ CGVYLFADRH EHRVDFRVIL YHNDPARDVV
     HVVRDWQEDY IGKGWGPLRF INRFTLEQDG FLVHGCLRVG IEVLSGLY
//
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