ID A4H4Y3_LEIBR Unreviewed; 828 AA.
AC A4H4Y3;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_07_0390 {ECO:0000313|EMBL:CAM41651.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41651.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM41651.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41651.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000256|ARBA:ARBA00006608}.
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DR EMBL; FR798981; CAM41651.2; -; Genomic_DNA.
DR RefSeq; XP_001562535.2; XM_001562485.2.
DR AlphaFoldDB; A4H4Y3; -.
DR STRING; 5660.A4H4Y3; -.
DR GeneID; 5412957; -.
DR KEGG; lbz:LBRM_07_0390; -.
DR VEuPathDB; TriTrypDB:LbrM.07.0390; -.
DR VEuPathDB; TriTrypDB:LBRM2903_070010300; -.
DR InParanoid; A4H4Y3; -.
DR Proteomes; UP000007258; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131:SF94; MATH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 2.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 296..336
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 421..455
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 709..823
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 421..455
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 86359 MW; 3AC2AC9A0FCF1EB4 CRC64;
MSSWTNAPAS SCAAAAPNHL PGTSTSPSAT CRRREAAVYP TSGAAPTFLG AVITFGASGC
MATPLVAAPG THCDDHTPTC TAARVAPAPP SGAPSAAAAA GQHDCVSQDF SGPLQRPSPT
VLHLYATTTT AAGTANPKRR HGLLPPPIMS DVTRALGHRS CSCPNTRSTP AADAAIASSP
VSTNSGVVTR SRAAVAATNS SSTLQVTGNQ SSPNDMLTKE TVPFPIYSFK PLGLWSALPT
TGVTATAAVS ASATTLELEA STATTNGVDV GTLLTHEMDS GVVIVDPCQT PDDLVCGVCM
SVCRHPTATT CGHLFCRRCL QGWMQANPAA MCPLDRTPIQ VELLHTDARA QRQINALPCH
CPASLSRASQ LELRQLGSAH RVLGDGTAEE GGDVGGTRGD ECARQAHPRC TWAGCVSDAA
AHMCQCPHII IECPFAKHGC AVELPRSDMA SHLKNYVADH LLLLSQALDA SVEQCRALQG
EVEVLRQRCP MRYPVALPNV PTGGPTGSSA PTISVSSSLL HGATTATSVP GMDVPTAVPT
PALVISNGSS SGAATIAMAA LPEEVSMSSV SLLRVAGSFG HGASTAVDYP SPVFSQSLRP
YYHLHHRSST AVEPTNLRRG TATEDMLLAA THRVPNGHDA TTPMAMDTTP VRTPSPSRLG
ASPGSVPVAN LAAAAATFVL PPGAATLLPT PVASAPSRAA PVVGGICGVD RFVWVITDVA
SLQAPCYSRP FSSHNVPWYV GMDTTATWEQ CGVYLFADRH EHRVDFRVIL YHNDPARDVV
HVVRDWQEDY IGKGWGPLRF INRFTLEQDG FLVHGCLRVG IEVLSGLY
//