ID A4H5Z8_LEIBR Unreviewed; 691 AA.
AC A4H5Z8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Putative nucleoside phosphatase {ECO:0000313|EMBL:CAM37219.1};
DE EC=3.6.1.42 {ECO:0000313|EMBL:CAM37219.1};
GN ORFNames=LBRM_10_0170 {ECO:0000313|EMBL:CAM37219.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37219.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37219.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37219.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37219.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37219.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; FR798984; CAM37219.1; -; Genomic_DNA.
DR RefSeq; XP_001562788.1; XM_001562738.1.
DR AlphaFoldDB; A4H5Z8; -.
DR GeneID; 5413270; -.
DR KEGG; lbz:LBRM_10_0170; -.
DR VEuPathDB; TriTrypDB:LbrM.10.0170; -.
DR VEuPathDB; TriTrypDB:LBRM2903_100006600; -.
DR InParanoid; A4H5Z8; -.
DR OMA; RVHVYKY; -.
DR Proteomes; UP000007258; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IEA:UniProtKB-EC.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF120; PHOSPHATASE, PUTATIVE-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000313|EMBL:CAM37219.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 434..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 343
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 376..380
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 691 AA; 74840 MW; 7B2B2664D43E39C9 CRC64;
MAVVGGFTAG KPLRGMGRIV LGLFAVMLVA FVITAYQVGV STANPRQSRH IQLAQNAVAK
SEAMLTGCRE ANANLKNSGS VKGAQAIAEM ARQKAELTST VALERERVVS ARSLLQACED
GLASEHRTLF GTAHRNTTAH LLWLKQRRAH LKSEHEKLTE GPLGVVEPRR SSGIRALQAA
LLQEIHPSTG LAGNGVENRK ACVDAVAKYS VVFDIGSTGN RVHVYKYRVN PLTQISASAP
DELSKIDLVG ELFELNYKAL SELNNPVQDA PEALWELFAK AKNFVPAELH ACTPIEFKAT
AGLRMLGLEK ATEILAEIRA RYRKETFWLR GSAPVRILDS HEEGLMAWLT VNFLLGTFAR
NTEATASTAA IIDIGGGSTQ IVFEPGEDTF YKMRADVRGS ATLGGRSVKV YQHSYEGYGL
HAATKALLFH IQGKRQERPG GGSATRATTT ARTSGDDSTP SVGNGVRNVS ANDSKDEEDE
NMITDTAPPK TLPWLQLDTE AVDAFPCFAV GYEDQLGVRN TKRNDAGEPA RHPDFQACAN
LFRDRLLKPV GLTCEEVNCG VAGVFQPPLA NFTGDIYAFS FLFDLLAMAN NSLAPVGAAV
SNDKFEVKLP DLAKIGERHC AAFSLTRIAE ATAKGGLGSL KPEYECMYYS YTYALLRYGY
EVPEGRVLHV AKKISGYETA WPLGASLISV T
//
