ID A4H8V6_LEIBR Unreviewed; 688 AA.
AC A4H8V6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Putative receptor-type adenylate cyclase {ECO:0000313|EMBL:CAM37824.1};
DE EC=4.6.1.1 {ECO:0000313|EMBL:CAM37824.1};
DE Flags: Fragment;
GN ORFNames=LBRM_17_0110 {ECO:0000313|EMBL:CAM37824.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37824.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37824.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37824.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37824.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37824.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798991; CAM37824.1; -; Genomic_DNA.
DR RefSeq; XP_001563779.1; XM_001563729.1.
DR AlphaFoldDB; A4H8V6; -.
DR STRING; 5660.A4H8V6; -.
DR GeneID; 5414309; -.
DR KEGG; lbz:LBRM_17_0110; -.
DR VEuPathDB; TriTrypDB:LbrM.17.0110; -.
DR InParanoid; A4H8V6; -.
DR OMA; PFMANDA; -.
DR Proteomes; UP000007258; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028082; Peripla_BP_I.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CAM37824.1};
KW Receptor {ECO:0000313|EMBL:CAM37824.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT NON_TER 688
FT /evidence="ECO:0000313|EMBL:CAM37824.1"
SQ SEQUENCE 688 AA; 74486 MW; 7D83AFBCAB9316A9 CRC64;
MACWTLAATT CRRTCCVGAG AGLRLVALAV LAVVAAALSA APPALAVDGN GGGSNDPVYL
LNAMYSLDPF MANDAKALWL GIDAALYASG YKTANGRPIK IVDPDPKVDP SNITAVVRKA
LEDYPTLLGV IGPFLDPLMW SVLETAAFRD MDLMFLGPFT GSSAVRVWSD SVYYMRAEPR
TEITVMLTHI LKTIRARRTA FMYLTGVQFG DSEYQMVRAV FASFSLEPPA LYSAPHSMTD
SAVDMTVFDA MANTYPQVII LWGMPGRQVA EFLRVVLTDP RTSSAYIMTC FPLQRIAFQV
YYDLAMAGKL TPVDGQLMSS ANTLPVSYAN VQHVELFRAE MGKYMEQTGR VDASLWADEA
KAVREYGPWG HEPPSSDSAA DVRRFFNEHP SSTQLMFAGW LPGKVIMQTL DQPLWITDRR
AYVTGLFDQN RYMIAGDIVI GDYGAPCTPV AAFLGAVCYC NQGGRAAILQ HLHKASWTFS
FQSAFNYAQS VCYLKNIAVS KPLSALILNF SDLPKLTAAA ARMRTVIQNA VDGSGLDFAA
FNPAMLNATQ ATGQGILDRE LLNYTVDVIT GPLLRSIDVN GTLVISPVFN RPSIVVPKSN
YLFLMPTLEQ EMYVLYSRMA VVTAVTSISA GVNLVLHEYS SASVRDITAL GVKTAATFNL
PDPSTAGISP GASVATSLAP DKINFVLG
//
