ID A4HBQ2_LEIBR Unreviewed; 262 AA.
AC A4HBQ2;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Dihydrolipoamide acetyltransferaselike protein {ECO:0000313|EMBL:CAM38841.1};
DE EC=2.3.1.12 {ECO:0000313|EMBL:CAM38841.1};
GN ORFNames=LBRM_21_0610 {ECO:0000313|EMBL:CAM38841.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM38841.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM38841.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38841.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM38841.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38841.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
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DR EMBL; FR798996; CAM38841.1; -; Genomic_DNA.
DR RefSeq; XP_001564770.1; XM_001564720.1.
DR AlphaFoldDB; A4HBQ2; -.
DR STRING; 5660.A4HBQ2; -.
DR GeneID; 5415326; -.
DR KEGG; lbz:LBRM_21_0610; -.
DR VEuPathDB; TriTrypDB:LbrM.21.0610; -.
DR VEuPathDB; TriTrypDB:LBRM2903_210010700; -.
DR InParanoid; A4HBQ2; -.
DR OMA; LAKIYCG; -.
DR Proteomes; UP000007258; Chromosome 21.
DR GO; GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:InterPro.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR045257; E2/Pdx1.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR23151; DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR23151:SF90; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:CAM38841.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:CAM38841.1}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..262
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002668975"
FT DOMAIN 12..88
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 262 AA; 27196 MW; 93D4E6FC5F9E9EAB CRC64;
MMRRTLLWLV NFEPVFMPAL SPSMERGTVV EWKKKVGDVV NENDVFCTIQ TDKAVVDYTN
TFESGYLAKI YCENGQSAPV AKTIAVMVSD AADVEKASNY YPEDAATAPA TAPAAADAAQ
DPPVSSAAPA KHYGGSIDAA VAASGPSVTR IVAGLEPSAL AGIAPSGKGG RFLKSDFSDQ
PGFKYSDTAP ARATRKEVPA AAAGDTSKTA AKSVAGTAVS GSIYDVVLKP GPAYKSVSDT
ALLNKLIRAM YVPKPNANKA AK
//
