ID A4HDD3_LEIBR Unreviewed; 1126 AA.
AC A4HDD3;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Putative DNA repair and recombination protein RAD54 {ECO:0000313|EMBL:CAM42253.1};
GN ORFNames=LBRM_24_0770 {ECO:0000313|EMBL:CAM42253.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42253.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42253.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42253.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42253.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42253.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798999; CAM42253.1; -; Genomic_DNA.
DR RefSeq; XP_001565343.1; XM_001565293.1.
DR AlphaFoldDB; A4HDD3; -.
DR STRING; 5660.A4HDD3; -.
DR GeneID; 5415922; -.
DR KEGG; lbz:LBRM_24_0770; -.
DR VEuPathDB; TriTrypDB:LbrM.24.0770; -.
DR VEuPathDB; TriTrypDB:LBRM2903_240013600; -.
DR InParanoid; A4HDD3; -.
DR OMA; TITCASQ; -.
DR Proteomes; UP000007258; Chromosome 24.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR CDD; cd18004; DEXHc_RAD54; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 453..623
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 800..956
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1126
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1126 AA; 123481 MW; 39886015FFD748B4 CRC64;
MRKSTAGSGV ANGTFRPPTT SGEDKPAARK PSVHPLLPAT SASAVPRFMT GWRALSSGSC
KAPGSGDSRN TNDSAADLPG PTVALVTSTG VRREVMYPTV TPHSAGSTAN NDLLAHRLAR
RSQIDYHQPE SASKAVVART LQAAAAAQGK TGDEAEDCED QGSGAAKLIR VEAGAGGVKS
VPSAPEAADG NAASAAKGSH EAAAAAANDD AIPTDKVVSC YPASPYGKLY FQVETDGATR
HESVGIVIID TELLGVMMYD RVGRQYGNRP DPGYPIKQEE VDNAKAGSTL KVGTKHVLLI
TALTEEAFRS GEFFLRSEHD LRVREDKAKA KADAAAAEEA KARKPEMSFG ISLGNNSAFA
SILFRRRPKD GETGFVVPVA GRPKMGKNGI IMNELRPLHD PDREKAVVLF RADYKRDLHG
RRQVSVVVDP IIGDKLRPHQ IIGVKFLFDC ITGERMLGYH GAILADEMGL GKTIQTVATI
YTCLKQGKHG QPTARKCLVV TPSSLVKNWC NEFDKWLGEG AVKHFAISES TPKGDRIISR
FDGDGDVLVI SYDQLRKYID RLSRLRFVEL VVCDEGHRLK NAEVKTTKAV DMLPTRNRII
LSGTPIQNDL SEFHAMVNFV NPGILGNRDL FTRVFEEPVS LGRDPDCPDH LKSLGRDRAH
YLSMLTQRFI LRRTQSINES YLPPKVDVTV FVRLGAKQEQ AYQKLADIVE SAECTPLVLI
SALRKLCNHM DLFHDAVHLS HQVGNGIGAS AQQQQAGRRR GRSSAADEPQ GIPFSVLPKG
FKPGSLSMDY GSKMHFVSLV LDELRENGEH DKLVIVSNFT QTLDIIAALC NSKRIAYFQL
DGSTPIKKRQ QLVDYFNVPD SQEVVFLLSS KAGGVGLNLI GANRLILFDP DWNPANDAQA
MGRVWRDGQK KRVFIYRLLS TGTIEEKIYQ RQVSKQGLSA NVVDMQEDSK QHFTLEELKS
LFKYKVDTLC DTHDLLGCTS CEAAEPLATS DRGSRSKQAE ELKMQFRKVG QPKKKSGPRM
DELKAWRHIS SVASFNLDSV TRAVARHAPS LLSFLFADER DNTKMPRPVV STRVKVDRPA
FEDDEETITC ASQAAIQQQE SEMEIEVIDD DDEEEGEFDS SEEESD
//
