ID A4HDF5_LEIBR Unreviewed; 664 AA.
AC A4HDF5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Putative replication factor C, subunit 1 {ECO:0000313|EMBL:CAM42275.1};
GN ORFNames=LBRM_24_1000 {ECO:0000313|EMBL:CAM42275.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42275.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42275.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42275.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42275.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42275.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116}.
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DR EMBL; FR798999; CAM42275.1; -; Genomic_DNA.
DR RefSeq; XP_001565365.1; XM_001565315.1.
DR AlphaFoldDB; A4HDF5; -.
DR STRING; 5660.A4HDF5; -.
DR GeneID; 5415944; -.
DR KEGG; lbz:LBRM_24_1000; -.
DR VEuPathDB; TriTrypDB:LbrM.24.1000; -.
DR VEuPathDB; TriTrypDB:LBRM2903_240016000; -.
DR InParanoid; A4HDF5; -.
DR OMA; VKFPTWL; -.
DR Proteomes; UP000007258; Chromosome 24.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF08519; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 63..188
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 508..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 72513 MW; E5BA637259277F27 CRC64;
MVTMSASSAA DAAHPVTSRN ELWADKYKPR SIAEMCYPVC ANKLKAWLEN FTPIGSPGDD
PKKPHGVLLS GSPGVGKTTT VYVVARELGR TVVEYNASDF RSRKSLRENV SDLINNRAFS
ARATSYTTVV LLMDEVDGCD IGGVGEVIEM LKSTRIPILC TCNDRWHPKL RSLLNYVEDM
RFSHPPCNVV ANYLCDRVLA REGISLSKPL LQDIIKTSGS DIRSMLNNLQ LWCLRRISLE
QRQLAECAAQ STKDSDAGLF DAAEYFLLQG TSRGERHSIA EMQARYYNAD LVDMFVQENY
LHYNPQLVDG RDWMEAVSQA ATSISRADAA QRIMYYEQNW SVSRFHVLSS SIAPCVYTRG
KYETFMTGQQ KFFDMQRPVK FPTWLGHNSS ANKNRRLLRC VAMQASHPAK GVSGNQEDVV
ADYMPHGWER PLTVPLATKG KDGIADVIAS MDQYNLMRDD WDLVQTLPHY KHMQSPSSMA
PPVNITTAVK TAFTREFNKT HRFDSFAKSA LKRGDEETQE DEEGGQGTGA GGNRKAGKVA
MDGVTVVSVT GNGAAVTKKK GKVAAGAATI STTAAATRKP RAKKSTPADG AARTTAKKAP
KSSTRVKAKA SPATTNAKRK RARATSSESE EESMSSLSSA SSSSAPSSSS SSSSSSSSDT
SDSE
//
