ID A4HDY9_LEIBR Unreviewed; 1075 AA.
AC A4HDY9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Kringle domain-containing protein {ECO:0000259|PROSITE:PS50070};
GN ORFNames=LBRM_25_0420 {ECO:0000313|EMBL:CAM39041.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39041.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39041.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39041.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39041.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39041.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799000; CAM39041.1; -; Genomic_DNA.
DR RefSeq; XP_001565547.1; XM_001565497.2.
DR AlphaFoldDB; A4HDY9; -.
DR STRING; 5660.A4HDY9; -.
DR GeneID; 5416131; -.
DR KEGG; lbz:LBRM_25_0420; -.
DR VEuPathDB; TriTrypDB:LbrM.25.0420; -.
DR VEuPathDB; TriTrypDB:LBRM2903_250010400; -.
DR InParanoid; A4HDY9; -.
DR OMA; SWHVATP; -.
DR Proteomes; UP000007258; Chromosome 25.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR038178; Kringle_sf.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1075
FT /note="Kringle domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002669811"
FT TRANSMEM 1033..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..134
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT REGION 992..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 114315 MW; 7AF41419F7163673 CRC64;
MLRIHQRVMW ASTPVASAVL VLAAVLVLFP GSTAAEPAYA ARATAAGSTC DSRTHVYYHP
DGQDYRGTVN VTESGIPCQM WSWGTPHSHM IPLDSATGVG SHNYCRNANG LERPSCFVAT
PGGGYQFCAI GGVCTERSFA KPTVQFWPVS GTQIAADGGS NYVALSCYPR PCRIHYVLGA
EALASATSPV YTQPILLEGS TTVKAYVMYE TADPMRVQAW CTVIPATTAA PDSSTRFIPS
DAAAYHYPIF VELQGATNAS HVLLYWNDDL VNPTTYTGGV FRPKTSTSIV AVVNSTHLVA
ASYKLNITAP PLQVFPPSGT YLGGVSVLVV DPQSPAMYYM YVNRSAEWES LDALLFPWTA
IGTSEPGAYT VTCPYADDLK ATHATTGILQ WVAVPMQLPT FTPACGTNFP AIALSLQVGL
SVSSLPRGGL ATLWFVSASA TDGARIPMIT RSTDDDGVFV YDIFQSKSIQ VPTTMEVYVT
SRSLDPLEAD SPQATCAYSL YPLGASTTPY FSAIPNCATT SVPVSPSCVM ALRLQLASCL
HFYTTELLSI DCIGPIVLMR MTGLAAAIQS DMYTRMGACL ADLQRRGVFS DVRNETSGEM
VLAMSWHVAT PTHMAAQVYR GLPTTVHITG FHAEAGAYHL VRSDDNCEDL GVLPETTLSR
PPYATAAAGS SPVSPSSAGS IYLTFRVPFA GQYKLCSYIS DSLYEVPFSS SEVGAATPAV
TQYLDVVVQP WLIVSATPAE ERGGLVPYDM EGVPFALSMA TTPAGAYASL AYSSNSADWQ
SVPFPIDVTT NLGGAVSVSV GPLNHQTRPL EVLDASLVPA SGAAQTSLFV SAANPLVQRE
RITYLFYTVS ASEVPAPLTG VMLLLQGQFQ PDELIVIDVY ENVSLTTAGD RASFSLQLLR
RVTARPSAAT AYTVALPDAV LGLPAGLQHI PYVVYATLDG AHVTTSPLSV ALSPLALAMT
SCTTCSSRLC YNEYCLCKNK RTKVVFICET DSGESGSNDS GDLPDGSGSK SSSSTSDSGD
DNDIKPATMS QRLAFLFAYL GLLALIGGYI LISMRRSGTR RERALHAQDI SIESS
//
