ID A4HEY9_LEIBR Unreviewed; 633 AA.
AC A4HEY9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Putative DNA ligase k alpha {ECO:0000313|EMBL:CAM39398.1};
DE EC=6.5.1.1 {ECO:0000313|EMBL:CAM39398.1};
GN ORFNames=LBRM_26_1360 {ECO:0000313|EMBL:CAM39398.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39398.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39398.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39398.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39398.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39398.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR EMBL; FR799001; CAM39398.1; -; Genomic_DNA.
DR RefSeq; XP_001562367.1; XM_001562317.1.
DR AlphaFoldDB; A4HEY9; -.
DR STRING; 5660.A4HEY9; -.
DR GeneID; 5416488; -.
DR KEGG; lbz:LBRM_26_1360; -.
DR VEuPathDB; TriTrypDB:LbrM.26.1360; -.
DR VEuPathDB; TriTrypDB:LBRM2903_260018700; -.
DR InParanoid; A4HEY9; -.
DR OMA; FECCDDA; -.
DR Proteomes; UP000007258; Chromosome 26.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR029319; DNA_ligase_OB.
DR InterPro; IPR025487; DUF4379.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR47810; DNA LIGASE; 1.
DR PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR Pfam; PF14743; DNA_ligase_OB_2; 1.
DR Pfam; PF14311; DUF4379; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000313|EMBL:CAM39398.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 386..570
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 27..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 69024 MW; 6BB2FD4CE79897C7 CRC64;
MMKATVLLRL GGGGSGLIGR PTLLRRQTAK RVATTKAKDT TTGGRNKKAT APTADGGWCS
HKLSLADFHP AIARTWIAAA SNKMLQPQHV TPDSRKLAWW ICPSCHHQHN KRIDRHLAAG
GACPQCGAKP TLDVGRSARK DASSPRSASN AASLSTKTKR TTAASAQKSV PAVAVLRHRC
RPSSTLDTIA APNANLLSKS VADDQYLRVQ ETRNLLPMLA KSYDKERWKI ASDEVLQVSP
KLDGIRCVAA YRVDTKQVLF FSRSGTLFEC CDDAIEPALR HLFEKDPTLV LDGELYNDSV
NLVQLSTVRT AAGKSPRLSP TAALSGEDPV SAFYNSLLAA AYGNKKHKHN SVAAAGVAQT
DLPAVIRFDQ LTSAIRTTRQ WLTPEVSALQ RQLQYHVFDI LYSREFPGGR GSAVPFSVRY
GVLERLLASV TVHNLAHISR YDPLVLRRVP SYLCTIDAVD TVLHAAMRVG YEGIMIRREC
RGATTVADRD SNKVESAVKK IKRGSASNEG KARAGAATEN SDGGYGYGQR SSTLLKYKVM
QDAEYVIVGA VEGSGKWKGF LGSFICVTPD KKHRFTVTPA STDAEKRRMW QSWKTAYKGK
VLTVQYQEIT PDGVPRFPVG KCVRGAADGH DWL
//
