ID A4HF44_LEIBR Unreviewed; 352 AA.
AC A4HF44;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Methyltransferase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_26_1920 {ECO:0000313|EMBL:CAM39454.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39454.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39454.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39454.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39454.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39454.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799001; CAM39454.1; -; Genomic_DNA.
DR RefSeq; XP_001562422.1; XM_001562372.1.
DR AlphaFoldDB; A4HF44; -.
DR STRING; 5660.A4HF44; -.
DR GeneID; 5416544; -.
DR KEGG; lbz:LBRM_26_1920; -.
DR VEuPathDB; TriTrypDB:LbrM.26.1920; -.
DR VEuPathDB; TriTrypDB:LBRM2903_260023900; -.
DR InParanoid; A4HF44; -.
DR OMA; SWWEDAT; -.
DR Proteomes; UP000007258; Chromosome 26.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR45445; -; 1.
DR PANTHER; PTHR45445:SF2; METHYLTRANSFERASE; 1.
DR Pfam; PF13489; Methyltransf_23; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 352 AA; 39735 MW; 2DE22442E83389E9 CRC64;
MQQLSAVVSN ELSELTKSWT PEQQKLYGVV SLTAVVAAGT PMIGVSVMRR CCCGHCRRDV
GGSDVAFSES HSKSSDIYES EALARQYMEF HYTPSHESYT QRLQSVSEAY DFPTRVAQKF
RTYIQTGKRN LRGLDIGCAT GASVLEMSKV FDGGVIGIDF SEVFIHLAKE VVNQATSGKR
VAYTAPVQGE ITEPRELQLP REARPDRCEF YAGDAMNMFE EDHKITTKAS RLYPNVKYWQ
ARKGETFDGV LCLNLIDRVP DPQRLLDSFA RLLAEDGILI LADPYSWWED ATEKSRWLGG
RKENGIRSEE AVKAALASKL ELLSESDEPF LIRDHIRHYQ LGFSHCTVWR KK
//
