ID A4HG79_LEIBR Unreviewed; 392 AA.
AC A4HG79;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN ORFNames=LBRM_28_0390 {ECO:0000313|EMBL:CAM39569.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39569.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39569.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39569.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39569.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39569.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR EMBL; FR799003; CAM39569.2; -; Genomic_DNA.
DR RefSeq; XP_001566073.2; XM_001566023.2.
DR AlphaFoldDB; A4HG79; -.
DR GeneID; 5416945; -.
DR KEGG; lbz:LBRM_28_0390; -.
DR VEuPathDB; TriTrypDB:LbrM.28.0390; -.
DR VEuPathDB; TriTrypDB:LBRM2903_280009400; -.
DR InParanoid; A4HG79; -.
DR Proteomes; UP000007258; Chromosome 28.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 7..132
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 392 AA; 41991 MW; E91F8BE6A10F696E CRC64;
MASKLDIIVL GATGFTGRLT CRYLARKEEL KERWGIAGRS AAKLAALKAE LGIDVPTFVV
DADQPTTVDA ACAQAECIIS CMGPYMLVGM PVVDACVRNG THYIDCTGEI PFVRRAIAAY
HETAVKKGVA IVPCCGFDCV PADLGNYVVH QEAEEPVKVV CGYFGGNPAG VSNGTMNTVA
CVVSNMTKED MSPLALVSKS DVQPTHTPTQ HGVWYENGRF TGLSITASCD ERLVRRSNSL
MGSSAVYMEA MQGSFARVLR VTLTTYVASI AVMVAPLRRW MIRKYFTGTS IGPSDDAMAK
SNFRCDFVGK TASGKRVKTT MAAKEDAYTA TALFLGECAM SALKLARKNS LKGGVLTPAY
AFGDELVHRC RDAGISINTV IVGDTAEPKK EK
//
