ID A4HH28_LEIBR Unreviewed; 1591 AA.
AC A4HH28;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=SNF2 DNA repair protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_29_0210 {ECO:0000313|EMBL:CAM39877.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39877.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39877.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39877.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39877.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39877.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; FR799004; CAM39877.1; -; Genomic_DNA.
DR RefSeq; XP_001566369.1; XM_001566319.1.
DR STRING; 5660.A4HH28; -.
DR GeneID; 5417253; -.
DR KEGG; lbz:LBRM_29_0210; -.
DR VEuPathDB; TriTrypDB:LbrM.29.0210; -.
DR VEuPathDB; TriTrypDB:LBRM2903_290007400; -.
DR InParanoid; A4HH28; -.
DR OMA; ASHICLH; -.
DR Proteomes; UP000007258; Chromosome 29.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR044574; ARIP4-like.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45797:SF1; HELICASE ARIP4; 1.
DR PANTHER; PTHR45797; RAD54-LIKE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 72..327
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 499..652
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1591 AA; 175919 MW; EEEBBBFBB6E3A447 CRC64;
MSTVATDAGS SSSGCVDCSS LRHVTLELPP VMESVLRPHQ VNALEFIWKR LVLDGALRLA
ARTFSSTIEQ RTRLYQEVFG VILAHSMGLG KTLTSLSFVL LFQAQTMLMA MKRDRVRQHQ
QQQSERASTA VATGLVPKGA ACPALRVLVL CPRSCVLHWQ ASISEWIQPR YAGTMRVNSY
VPSAMGISLN AMHRSSGGHS IEEVLLSYYQ KGGLLLLGYE EYQRILQYAQ AQYRSNPTNT
WPRVWSLLDR LRLHLPLFQE VRLLDIIETA DLVILDEAHR LRRSSSNLVT ALARHLRNIQ
LRLALTGTPL QNHLEEYNTM QSIVTGRELD TQLFHKHFIA PIERGQCVDS TYPQFLEMQR
CIASLRRYFA DSAHHCGPEV LAATLPPRRE FLFFFRLSAA QEVAYKAMLK RFHTQVAAGE
KGDSVLRLHH VASHICLHPA LSELEASSSS TALVSGKDGE EDGDDEDEDA TPVVSSTLPA
AALSNLDVSV SPKLSFAFYL TLHIVREQRE KVVIFSQYLS HLRLMAQLLA REGISAPSLT
GTSSDTERCR CIAELQSNDA CRVLLCSVRA GGVGIKLTAA SHCILLDVSW NPTDDVQATY
RLYRYGQLRP VNVYRLATWG TSEHVVFAYA LQRAWLQKKI ADITDPRRQQ RHQTRSYFRY
PCAVPLPEDG SGVTTDEQVT LPLSQSSLKE TLASNRRLEY ALGVCETQCA VAAHVLRMHP
EEKGYLYTVI PQSVLLLHNE DDVIRERGRR FEDAAQKSRA SVAIPLQVTS GGAASAQSRE
DLSLLDACEA ELVDAARQAA HLVITHVLRT REEAVSGRDA ASEVHTVDQT MCQRLQPLLI
PALEARPPPR FLAEVLLLCY QAGAADVFRT LLQSSAYLKL RTYLASRVPA AGRRRTRDTA
LPSRSPLEDA LLFTPVSLFK SMSSVEATYV ATELGCDRPF VGFCMLHGLQ KLWYVDGRLA
LSETTLEALA ALLGIIPGRV DGDSDSEEVE EAVEGEDGVR VRSRRDADGA FAETVPALAQ
SVLAAMASCL EEQWPPYEGF TLPPQHLQLE REEMRIGRAY RAASRAHMEG LLPLSQVSDL
LRLPSYRQGQ HMYGCARCRS PLLQRLDATH LECPRCHYNA EFEVRADPRM QQQTVLYQLS
VVANLLDAFS ITKSFAVSFS PSECGDVSAA LREVHTSQAV FEFVRRAMEE GVRAFLSEYP
PRLVRLLGLQ LGTGGDVEEL RRVLLANGRL ASHTNVREHL RERLAQAFAD FVHPSTLTQF
VAMPLMFLVT ALHYLARCER LSYAHELLLD ECPTPRRKLL RFASDALVKV LYVERLLKHC
RQKPLPSSYA SSISVAASSA TLGMGTGAQQ ENVVSSNGDG AGSLTSLLMA ASSSAGSQSQ
PCISTSSSSS FHSDSSGGSR SDNAAGARRS HKDPLLHAMD SSQNGRSGSG SRATSTTSSS
SARPSSSSSF NSVYSGDRAS FPDGSASDAE ERDEAMRGQQ DTVTWLEELA RNTLERAAPT
AEELESEAVQ QQRSAQYWIA FCEVYGTHSA ETLTVYIEDK ESGAKVLPPP PLSFWISQVA
HTTMVGYCMT DMLDIFFKKV LELSQQVRVI S
//
